Search by BoMiProt ID - Bomi4708


Primary Information

BoMiProt ID Bomi4708
Protein Name Chymotrypsin-like elastase family member 2A/Elastase II/Elastase-2/Elastase-2A
Organism Bos taurus
Uniprot IdQ29461
Milk FractionWhey,Casein
Ref Sequence Id NP_777139.1
Aminoacid Length 269
Molecular Weight 28857
Fasta Sequence https://www.uniprot.org/uniprot/Q29461.fasta
Gene Name CELA2A/ELA2/ ELA2A
Gene Id 282687
Protein Existence Status reviewed

Secondary Information

Protein Function circulating enzyme that reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.
Biochemical Properties exocrine pancreatic elastase that preferentially cleaves A-acetyl-L-alanyl-L-alanyl-L-alanine/proline methyl-ester.There is a C-to-A transversion (chr1.15,789,253C-A, GRCh37) in the CELA2A gene, resulting in a leu85-to-met (L85M) substitution at a highly conserved residue within the catalytic domain which is the cause of ABDOMINAL OBESITY-METABOLIC SYNDROME 4.The catalytic triad is made up of his45, asp93, and ser188.
PTMs Disulfide bond, proteolytic digestion
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Esteghamat, F., Broughton, J.S., Smith, E. et al. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nat Genet 51, 1233–1243 (2019). https://doi.org/10.1038/s41588-019-0470-32.Szepessy E, Sahin-Tóth M. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. Pancreatology. 2006;6(1-2):117-22. doi: 10.1159/000090031. Epub 2005 Dec 1. PMID: 16327289; PMCID: PMC1447606.