Primary Information |
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| BoMiProt ID | Bomi4539 |
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| Protein Name | C-C motif chemokine 2 |
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| Organism | Bos taurus |
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| Uniprot ID | P28291 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776431.1 |
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| Aminoacid Length | 99 |
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| Molecular Weight | 11114 |
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| FASTA Sequence |
Download |
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| Gene Name | CCL2 |
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| Gene ID | 281043 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Acts as a ligand for C-C chemokine receptor CCR2.Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions .Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils.Plays an important role in mediating peripheral nerve injury-induced neuropathic pain.Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. |
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| Significance in milk | CCL2 is a novel target for improving the quantity and quality of milk from cows through stimulation of proliferation on mammary epithelial cells and attenuation of LPS-induced inflammatory responses. |
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| PTMs | Disulfide bond,Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 3 disordered segment; (1-4), (11-16), (91-99) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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