Primary Information |
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| BoMiProt ID | Bomi4533 |
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| Protein Name | Caveolae-associated protein 4/Muscle-related coiled-coil protein/Muscle-restricted coiled-coil protein |
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| Organism | Bos taurus |
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| Uniprot Id | A5PJI6 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001096734.2 |
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| Aminoacid Length | 361 |
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| Molecular Weight | 41161 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/A5PJI6.fasta |
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| Gene Name | CAVIN4/MURC |
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| Gene Id | 528386 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | MURC is involved in the skeletal myogenesis that results from modulation of myogenin expression and ERK activation. MURC may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation. |
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| Biochemical Properties | MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance |
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| PTMs | Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A5PJI6|CAVN4_BOVIN Caveolae-associated protein 4 OS=Bos taurus OX=9913 GN=CAVIN4 PE=2 SV=2
MEHNGSASNADKIHQNRLSNVTEDEDQDAALTIVTVLDKVAAIVDSVQASQKRIEERHRV
MENAIKSVQIDLLKFSQSHSNTGYVINKLFEKTRKVSAHIKDVKARVEKQQTHVKKVEAK
QEEIMKKNKFRVVIFQEEVQCPTSLSVVKDRS*152LTESPEEVDEIFDTPVDLS*171S*172DEEYFVEE
SRSARLKKSGKERIDNIKKAFSKENMQKTRQNFDKKVNRIRTRIVTPERRERLRQSGERL
RQSGERLKQSGERFKKSISNAAPSREAFKMRSLRKTKDRAVAEGPEEVREMGVDIIARGE
ALGPISELYPEALSETDPEEASATHPPQEGGEVST*335PEPLKVTFKPQVKVEDDES*354LLLDLK
Q
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| Predicted Disorder Regions | 1-26, 52-60, 100-111, 159-168, 176-361 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Overexpression of MURC in C2C12 myoblasts resulted in the promotion of differentiation with enhanced myogenin expression and ERK activation during differentiation. |
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| Bibliography | 1.Tagawa M, Ueyama T, Ogata T, Takehara N, Nakajima N, Isodono K, Asada S, Takahashi T, Matsubara H, Oh H. MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis. Am J Physiol Cell Physiol. 2008 Aug;295(2):C490-8. doi: 10.1152/ajpcell.00188.2008. Epub 2008 May 28. PMID: 18508909. 2.Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Harada K, Takahashi T, Shioi T, Matsubara H, Oh H. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol Cell Biol. 2008 May;28(10):3424-36. doi: 10.1128/MCB.02186-07. Epub 2008 Mar 10. PMID: 18332105; PMCID: PMC2423172. |
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