Search by BoMiProt ID - Bomi4433


Primary Information

BoMiProt ID Bomi4433
Protein Name Calpain-3/Calcium-activated neutral proteinase 3/CANP 3/Calpain L3/Calpain p94/Muscle-specific calcium-activated neutral protease 3/New calpain 1/nCL-1
Organism Bos taurus
Uniprot IdP51186
Milk FractionWhey
Ref Sequence Id NP_776685.1
Aminoacid Length 822
Molecular Weight 94603
Fasta Sequence https://www.uniprot.org/uniprot/P51186.fasta
Gene Name CAPN3/NCL1
Gene Id 281663
Protein Existence Status reviewed

Secondary Information

Protein Function Calpain 3 is important for muscle regeneration
Biochemical Properties The model shows that the proteolytic domain can be subdivided into two globular subdomains (domain IIa and IIb), forming a catalytic cleft at their interface. As in ubiquitous calpains, domain III of calpain 3 fits a C2 motif.In this model, IS1 andIS2 have been structured as loops protruding out of the globular core structure. However, Diaz and colleagues have shown that, instead of protruding, IS1 is composed of an a-helix flanked by loops that close the catalytic cleft, blocking its access to substrates and inhibitors.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Loss-of-function mutations in the calpain 3 gene have been associated with limb-girdle muscular dystrophy type 2A (LGMD2A), a common form of muscular dystrophy .
Bibliography 1.Hauerslev S, Sveen ML, Duno M, Angelini C, Vissing J, Krag TO. Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies. BMC Musculoskelet Disord. 2012 Mar 23;13:43. doi: 10.1186/1471-2474-13-43. PMID: 22443334; PMCID: PMC3338386. 2.Duguez S, Bartoli M, Richard I. Calpain 3: a key regulator of the sarcomere? FEBS J. 2006 Aug;273(15):3427-36. doi: 10.1111/j.1742-4658.2006.05351.x. PMID: 16884488.