Primary Information |
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| BoMiProt ID | Bomi4421 |
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| Protein Name | Calcium-transporting ATPase type 2C member 1/ATPase 2C1/ATP-dependent Ca(2+) pump PMR1/Ca(2+)/Mn(2+)-ATPase 2C1/Secretory pathway Ca(2+)-transporting ATPase type 1/SPCA1 |
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| Organism | Bos taurus |
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| Uniprot ID | P57709 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_786979.1 |
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| Aminoacid Length | 953 |
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| Molecular Weight | 104780 |
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| FASTA Sequence |
Download |
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| Gene Name | ATP2C1/SPCA |
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| Gene ID | 327663 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | ATP-driven pump that supplies the Golgi apparatus with Ca2+ and Mn2+ ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway |
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| Biochemical Properties | ATP + Ca2+(in) + H2O = ADP + Ca2+(out) + H+ + phosphate |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 8 TMHs; (116-134), (138-156), (303-321), (333-355), (809-827), (842-860), (880-898), (907-929) |
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| Bibliography | Brown, J. M., & García-García, M. J. (2018). Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics. Development (Cambridge, England), 145(19), dev170019. https://doi.org/10.1242/dev.170019 |
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