Search by BoMiProt ID - Bomi4414


Primary Information

BoMiProt ID Bomi4414
Protein Name Calcium-responsive transcription factor/Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
Organism Bos taurus
Uniprot IdQ58CW6
Milk FractionWhey,MFGM
Ref Sequence Id NP_001027465.1
Aminoacid Length 703
Molecular Weight 78135
Fasta Sequence https://www.uniprot.org/uniprot/Q58CW6.fasta
Gene Name CARF/ALS2CR8
Gene Id 509072
Protein Existence Status reviewed

Secondary Information

Protein Function regulates neuronal activity-dependent expression of BDNF
Biochemical Properties Extensive analysis of the CaRF sequence has shown that it has no significant homology to any known proteins in the GenBank database and no domains that would identify it as a member of a family of transcription factors.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-151, 246-249, 524-538, 573-588, 614-635
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments CaRF is a neuronal nuclear protein with discrete DNA binding and transcriptional activation domains that can activatetranscription from the CaRE1 element in BDNF promoter III.
Bibliography 1.Tao X, West AE, Chen WG, Corfas G, Greenberg ME. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31;33(3):383-95. doi: 10.1016/s0896-6273(01)00561-x. PMID: 11832226.