Search by BoMiProt ID - Bomi4413


Primary Information

BoMiProt ID Bomi4413
Protein Name Calcium-binding and coiled-coil domain-containing protein 2/Antigen nuclear dot 52 kDa protein/Nuclear domain 10 protein NDP52/Nuclear domain 10 protein 52/Nuclear dot protein 52
Organism Bos taurus
Uniprot IdO18737
Milk FractionWhey
Ref Sequence Id NP_776825.1
Aminoacid Length 450
Molecular Weight 52551
Fasta Sequence https://www.uniprot.org/uniprot/O18737.fasta
Gene Name CALCOCO2/NDP52
Gene Id 281942
Protein Existence Status reviewed

Secondary Information

Protein Function The autophagy receptor CALCOCO2/NDP52 functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular pathogens and subsequently targeting them to the autophagic machinery.Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation.targets Salmonella Typhimurium to the phagophore membrane by concomitantly interacting with LC3C and binding to ubiquitinated cytosolic bacteria or to LGALS8/GALECTIN 8 adsorbed on damaged vacuoles that contain bacteria.
Biochemical Properties contains a dynamic unconventional zinc finger as well as a C2H2-type zinc-finger, and only the C2H2-type zinc finger specifically recognizes mono-ubiquitin or poly-ubiquitin chains.C2H2-type zinc finger can specifically bind to mono-ubiquitin or different linkage types of ubiquitin chains including K48-linked, K63-linked and M1-linked ubiquitin chains.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-10, 368-395
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Verlhac P, Viret C, Faure M. Dual function of CALCOCO2/NDP52 during xenophagy. Autophagy. 2015;11(6):965-6. doi: 10.1080/15548627.2015.1046672. PMID: 25998689; PMCID: PMC4502821. 2.Xie X, Li F, Wang Y, Wang Y, Lin Z, Cheng X, Liu J, Chen C, Pan L. Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2. Autophagy. 2015;11(10):1775-89. doi: 10.1080/15548627.2015.1082025. PMID: 26506893; PMCID: PMC4824588.