Primary Information |
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| BoMiProt ID | Bomi4413 |
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| Protein Name | Calcium-binding and coiled-coil domain-containing protein 2/Antigen nuclear dot 52 kDa protein/Nuclear domain 10 protein NDP52/Nuclear domain 10 protein 52/Nuclear dot protein 52 |
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| Organism | Bos taurus |
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| Uniprot ID | O18737 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776825.1 |
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| Aminoacid Length | 450 |
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| Molecular Weight | 52551 |
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| FASTA Sequence |
Download |
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| Gene Name | CALCOCO2/NDP52 |
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| Gene ID | 281942 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | The autophagy receptor CALCOCO2/NDP52 functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular pathogens and subsequently targeting them to the autophagic machinery.Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation.targets Salmonella Typhimurium to the phagophore membrane by concomitantly interacting with LC3C and binding to ubiquitinated cytosolic bacteria or to LGALS8/GALECTIN 8 adsorbed on damaged vacuoles that contain bacteria. |
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| Biochemical Properties | contains a dynamic unconventional zinc finger as well as a C2H2-type zinc-finger, and only the C2H2-type zinc finger specifically recognizes mono-ubiquitin or poly-ubiquitin chains.C2H2-type zinc finger can specifically bind to mono-ubiquitin or different linkage types of ubiquitin chains including K48-linked, K63-linked and M1-linked ubiquitin chains. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-10, 368-395 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Verlhac P, Viret C, Faure M. Dual function of CALCOCO2/NDP52 during xenophagy. Autophagy. 2015;11(6):965-6. doi: 10.1080/15548627.2015.1046672. PMID: 25998689; PMCID: PMC4502821. 2.Xie X, Li F, Wang Y, Wang Y, Lin Z, Cheng X, Liu J, Chen C, Pan L. Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2. Autophagy. 2015;11(10):1775-89. doi: 10.1080/15548627.2015.1082025. PMID: 26506893; PMCID: PMC4824588. |
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