Search by BoMiProt ID - Bomi4412


Primary Information

BoMiProt ID Bomi4412
Protein Name Calcium-binding and coiled-coil domain-containing protein 1
Organism Bos taurus
Uniprot IDQ2KJ21
Milk FractionWhey
Ref Sequence ID NP_001039900.1
Aminoacid Length 680
Molecular Weight 75661
FASTA Sequence Download
Gene Name CALCOCO1
Gene ID 538675
Protein Existence Status reviewed

Secondary Information

Protein Function CALCOCO1 as a novel ER-phagy receptor for the degradation of the tubular ER in response to proteotoxic and nutrient stress.Involved in positive regulation of gene expression and positive regulation oftranscription, DNA-templated.
Biochemical Properties CALCOCO1 is a homomeric protein that binds directly to ATG8 proteins via LIR- and UDS-interacting region (UIR) motifs acting co-dependently. CALCOCO1-mediated ER-phagy requires interaction with VAMP-associated proteins VAPA and VAPB on the ER membranes via a conserved FFAT-like motif.
PTMs Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q2KJ21|CACO1_BOVIN Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=2 SV=1 MEES*4SLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRD YHTFVWSLVPESVTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFRE PRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQ VQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTI SEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLEL QEAKDRQEEQSAQAQRLKDKVAQMKDTLGQVQQRVAELEPLKEQLRGAQELAASSQQKAA LLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVE AEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALR VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSE DESPEDMRLPPYSLCESGDSGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEA EDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFAVGPLTEASTGGPATPPWKECPIC KERFPVHTQTHTYTHTHTHA
Predicted Disorder Regions 528-617
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments Long noncoding RNA LINC00052 inhibits colorectal cancer metastasis by sponging microRNA-574-5p to modulate CALCOCO1 expression
Bibliography 1.Yu G, Xiong D, Liu Z, Li Y, Chen K, Tang H. Long noncoding RNA LINC00052 inhibits colorectal cancer metastasis by sponging microRNA-574-5p to modulate CALCOCO1 expression. J Cell Biochem. 2019 Oct;120(10):17258-17272. doi: 10.1002/jcb.28988. Epub 2019 May 19. PMID: 31104316. 2.Nthiga TM, Kumar Shrestha B, Sjøttem E, Bruun JA, Bowitz Larsen K, Bhujabal Z, Lamark T, Johansen T. CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy. EMBO J. 2020 Aug 3;39(15):e103649. doi: 10.15252/embj.2019103649. Epub 2020 Jun 11. PMID: 32525583; PMCID: PMC7396842.