Search by BoMiProt ID - Bomi4264


Primary Information

BoMiProt ID Bomi4264
Protein Name Beta-defensin 2/BNBD-2
Organism Bos taurus
Uniprot IdP46160
Milk FractionWhey
Aminoacid Length 40
Molecular Weight 4649
Fasta Sequence https://www.uniprot.org/uniprot/P46160.fasta
Gene Name DEFB2
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells Neutrophilic granules
Protein Function  human β-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. 
PTMs Disulfide bond formation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 13-34, 37-40
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments hBD-2 expression may be a result of local inflammation or the presence of invading pathogens.
Bibliography 1.Gu J, Huang Y. β-Defensin-2 is overexpressed in human vocal cord polyps. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):901-907. doi: 10.1007/s00405-016-4270-4. Epub 2016 Sep 1. PMID: 27586391. 2.Cieślik M, Bagińska N, Górski A, Jończyk-Matysiak E. Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response. Cells. 2021 Nov 3;10(11):2991. doi: 10.3390/cells10112991. PMID: 34831214; PMCID: PMC8616480.