Primary Information
BoMiProt ID	Bomi4240
Protein Name	Bcl-2-related protein A1
Organism	Bos taurus
Uniprot ID	Q3C2I0
Milk Fraction	Whey
Ref Sequence ID	NP_001032177.1
Aminoacid Length	175
Molecular Weight	20045
FASTA Sequence	Download
Gene Name	BCL2A1
Gene ID	282151
Protein Existence Status	reviewed
Secondary Information
Protein Function	Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury
Biochemical Properties	The C-terminus of Bcl-2 was important for other homomeric and heteromeric protein-protein interactions.three sites of homomeric interactions were identified within Bcl-2. The carboxy terminal 37 amino acids selectively homodimerized. Two additional regions of Bcl-2 (residues 1-129 and 126-200) interacted with each other, but not themselves permitting both intra- and intermolecular association.
Significance in milk	antiapoptotic in function,maintenance of binucleate cells and support placental functions during bovine gestation period
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	First thing is that Bcl-2 may exist as both heterodimers and heteromultimers. Second thing is that molecules such as Bax and A1 may serve to cap chains of Bcl-2 homodimers by interacting with dimerization domains in the extramembrane region.
Bibliography	1.Ushizawa K, Takahashi T, Kaneyama K, Hosoe M, Hashizume K. Cloning of the bovine antiapoptotic regulator, BCL2-related protein A1, and its expression in trophoblastic binucleate cells of bovine placenta. Biol Reprod. 2006 Feb;74(2):344-51. doi: 10.1095/biolreprod.105.042655. Epub 2005 Oct 12. PMID: 16221993. 2.Kurschner C, Morgan JI. Analysis of interaction sites in homo- and heteromeric complexes containing Bcl-2 family members and the cellular prion protein. Brain Res Mol Brain Res. 1996 Apr;37(1-2):249-58. doi: 10.1016/0169-328x(95)00323-k. PMID: 8738158.