Search by BoMiProt ID - Bomi4233


Primary Information

BoMiProt ID Bomi4233
Protein Name B-cell receptor-associated protein 29/BCR-associated protein 29/Bap29
Organism Bos taurus
Uniprot IdQ32KL9
Milk FractionWhey
Ref Sequence Id NP_001033164.1
Aminoacid Length 240
Molecular Weight 28212
Fasta Sequence https://www.uniprot.org/uniprot/Q32KL9.fasta
Gene Name BCAP29
Gene Id 511018
Protein Existence Status reviewed

Secondary Information

Protein Function play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.Involved in osteoblast differentiation. Located in membrane. class I molecules are largely recruited to ER exit sites by Bap29/31, and that Bap29/31 is a cargo receptor for MHC class I molecules.
Biochemical Properties The N-terminal half of proteins is membrane-bound while the C-terminal half is cytoplasmic also two coiled coils is present.The second and longest of these putative coiled coils also shares weak sequence similarity with the small six-helical DED domains, suggesting that it may adopt a DED fold. vDED domain contains little α-helix at pH 7.0 while a strong increase in α-helical structure is induced at pH 4.2.BAP29 vDED is much less stable than BAP31 vDED.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions (163-240)
DisProt Annotation
TM Helix Prediction 3TMHs; (7-29), (44-62), (104-122)
Bibliography Paquet ME, Cohen-Doyle M, Shore GC, Williams DB. Bap29/31 influences the intracellular traffic of MHC class I molecules. J Immunol. 2004 Jun 15;172(12):7548-55. doi: 10.4049/jimmunol.172.12.7548. PMID: 15187134.