Search by BoMiProt ID - Bomi4198


Primary Information

BoMiProt ID Bomi4198
Protein Name Autophagy protein 5
Organism Bos taurus
Uniprot IdQ3MQ24
Milk FractionExosomes,MFGM
Ref Sequence Id NP_001029751.2
Aminoacid Length 275
Molecular Weight 32431
Fasta Sequence https://www.uniprot.org/uniprot/Q3MQ24.fasta
Gene Name ATG5
Gene Id 532686
Protein Existence Status Reviewed

Secondary Information

Protein Function ATG5 is recognized as a key player needed for the formation of autophagosomes which is also important because of its potential contribution to apoptosis.
PTMs N-acetylation at Methionine, Isopeptide bond formation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Conjugated to ATG12 which is essential for autophagy.
Additional Comments ATG5 deficiency in melanocytes interferes with oncogene-induced senescence, thus promoting melanoma tumorigenesis. 
Bibliography 1.Liu H, He Z, Simon HU. Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis. J Mol Med (Berl). 2015 Feb;93(2):159-64. doi: 10.1007/s00109-014-1241-3. Epub 2014 Dec 23. PMID: 25529049.