Primary Information |
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| BoMiProt ID | Bomi4152 |
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| Protein Name | ATPase family AAA domain-containing protein 3 |
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| Organism | Bos taurus |
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| Uniprot ID | A7YWC4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001098932.1 |
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| Aminoacid Length | 586 |
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| Molecular Weight | 66107 |
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| FASTA Sequence |
Download |
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| Gene Name | ATAD3 |
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| Gene ID | 784353 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | mitochondrial protein synthesis and participate in mitochondrial DNA replication.. |
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| Biochemical Properties | a conserved C-terminal AAA+-ATPase domain (residues 320–518) that is present in flies, worms and mammals, characterized by ATP-binding and ATPase domains (Walker A and Walker B), including an SRH motif, sensor I and sensor II residues, and an arginine finger. |
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| Significance in milk | regulates milk biosynthesis and proliferation of mammary epithelial cells |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 12-43, 137-149, 570-586 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Baudier J. ATAD3 proteins: brokers of a mitochondria-endoplasmic reticulum connection in mammalian cells. Biol Rev Camb Philos Soc. 2018 May;93(2):827-844. doi: 10.1111/brv.12373. Epub 2017 Sep 20. PMID: 28941010. |
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