Search by BoMiProt ID - Bomi4138


Primary Information

BoMiProt ID Bomi4138
Protein Name ATP synthase subunit beta, mitochondrial/ATP synthase F1 subunit beta
Organism Bos taurus
Uniprot IDP00829
Milk FractionWhey
Ref Sequence ID NP_786990.1
Aminoacid Length 528
Molecular Weight 56284
FASTA Sequence Download
Gene Name ATP5F1B/ATP5B
Gene ID 327675
Protein Existence Status reviewed

Secondary Information

Protein Function It is a subunit of ATP synthase (F1F0 ATP synthase or Complex V) which is a part of ETS,producing ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.
Biochemical Properties β-F1 -ATPase forms the catalytic site of the enzyme ATP synthase
PTMs Acetylation, Glycosylation, Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P00829|ATPB_BOVIN ATP synthase subunit beta, mitochondrial OS=Bos taurus OX=9913 GN=ATP5F1B PE=1 SV=2 MLGLVGRVVAASASGALRGLSPSAPLPQAQLLLRAAPAALQPARDYAAQASPSPKAGATT GRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGES*106TVRTIAMDGTEGLV RGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQ EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERT REGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQD VLLFIDNIFRFT*312QAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAI YVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGS*415EHYDV ARGVQKILQDYKS*433LQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGK LVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHS
SCOP Class : All alpha proteins
Fold : Left-handed alpha-alpha superhelix
Superfamily : ATP synthase alpha/beta C-terminal domain-like and RecA-like P-loop NTPases
Family : ATP synthase nucleotide-binding domain-like
Domain Name : 2JDI D:127-445

Class : Alpha and beta proteins (a/b)
Fold : RecA-like basic
Superfamily : RecA-like P-loop NTPases
Family : ATP synthase nucleotide-binding domain-like
Domain Name : 2JDI D:127-445

Class : All beta proteins
Fold : ATP synthase beta-barrel domain-like
Superfamily : ATP synthase alpha/beta N-terminal domain-like
Family : ATP synthase alpha/beta N-terminal domain-like
Domain Name : 2JDI D:9-81

CATH Matched CATH superfamily
1.10.1140.10
2.40.10.170
3.40.50.300
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
PDB ID 1BMF,1COW,1E1Q,1E1R,1E79,1EFR,1H8E,1H8H,1NBM,1OHH,1QO1,1W0J,1W0K,2CK3,2JDI,2JIZ,2JJ1,2JJ2,2V7Q,2W6E,2W6F,2W6G,2W6H,2W6I,2W6J,2WSS,2XND,4ASU,4TSF,4TT3,4YXW,4Z1M,5ARA,5ARE,5ARH,5ARI,5FIJ,5FIK,5FIL,6YY0,6Z1R,6Z1U,6ZPO,6ZQM,6ZQN,7AJB,7AJC,7AJD,7AJE,7AJF,7AJG,7AJH,7AJI,7AJJ.,
Additional Comments Humans with obesity have lower synthesis rate of β-F1-ATPase and ATP synthase specific activity in muscle. These findings indicate that reduced production of subunits forming the ATP synthase in muscle may contribute to impaired generation of ATP in obesity.
Bibliography 1.Tran L, Langlais PR, Hoffman N, Roust L, Katsanos CS. Mitochondrial ATP synthase β-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity. Exp Physiol. 2019 Jan;104(1):126-135. doi: 10.1113/EP087278. Epub 2018 Nov 12. PMID: 30362197; PMCID: PMC6312454.