Primary Information |
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| BoMiProt ID | Bomi4054 |
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| Protein Name | Aspartate--tRNA ligase, cytoplasmic/Aspartyl-tRNA synthetase/AspRS |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SYZ4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001030257.1 |
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| Aminoacid Length | 501 |
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| Molecular Weight | 57036 |
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| FASTA Sequence |
Download |
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| Gene Name | DARS1 |
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| Gene ID | 510162 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | A tRNA modification factor.Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. |
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| Biochemical Properties | isoelectric point is 4.96 with a mol mass of 66,599kD.Cellular localization is Cytoplasm. |
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| PTMs | Acetylation, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3SYZ4|SYDC_BOVIN Aspartate--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=DARS1 PE=2 SV=1
MPSANASRRSQEKPREIMDAAEDYAKERYGVSSMIQSQEKPDRVLVRISDLT*52VQKAGEVV
WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV
RKVNQKIGSCTQQDVELHVQKIYVISSAEPRLPLQLDDAVRPEVEGEEEGRATVNQDTRL
DNRVIDLRTSTSQAIFRLQSGICHPFRETLTNKGFVEIQTPKIISAASEGGANVFTVSYF
KNNAYLAQS*249PQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH
EVVEEIADTLVQIFKGLQKRFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGI
EMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM
RGEEILSGAQRIHDPQLVTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF
LGLHNVRQTSMFPRDPKRLT*500P
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Cunha AF, Andrade HM, Souza FN, Fialho Júnior LC, Rosa DLSO, Ramos Sanchez EM, Gidlund M, Goto H, Brito MAVP, Guimarães AS, Lage AP, Reis LC, Della Libera AMMP, Heinemann MB, Cerqueira MMOP. Comparison of antibody repertories against Staphylococcus aureus in healthy and infected dairy cows with a distinct mastitis history and vaccinated with a polyvalent mastitis vaccine. J Dairy Sci. 2020 May;103(5):4588-4605. doi: 10.3168/jds.2019-17084. Epub 2020 Feb 26. PMID: 32113759. |
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