Search by BoMiProt ID - Bomi4045


Primary Information

BoMiProt ID Bomi4045
Protein Name Arylamine N-acetyltransferase 1/Arylamide acetylase 1/N-acetyltransferase type 1
Organism Bos taurus
Uniprot IdQ1JPA6
Milk FractionExosomes
Ref Sequence Id NP_001069040.1
Aminoacid Length 290
Molecular Weight 34199
Fasta Sequence https://www.uniprot.org/uniprot/Q1JPA6.fasta
Gene Name NAT1
Gene Id 512603
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells rumen epithelium
Protein Function Arylamine N-acetyltransferase 1 (NAT1) is a drug metabolizing enzyme that influences cancer cell proliferation and survival, especially in breast cancer.
PTMs N-Acetylation at Meth
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Lysine-acetylation is an important Post-Translational Modification (PTM) in the regulation of diverse cellular processes.
Additional Comments NAT1 is overexpressed in breast cancer, suggesting that it plays an important role in breast cancer development and growth.
Bibliography 1.Salazar-González RA, Doll MA, Hein DW. Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status. Front Pharmacol. 2022 Jan 27;13:797469. doi: 10.3389/fphar.2022.797469. PMID: 35153780; PMCID: PMC8828969. 2.Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells.Tiang JM, Butcher NJ, Minchin RF. Biochem Biophys Res Commun. 2010 Feb 26; 393(1):95-100. 3.RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition. Tiang JM, Butcher NJ, Cullinane C, Humbert PO, Minchin RF.PLoS One. 2011 Feb 9; 6(2):e17031. 4.Retrospective analysis of estrogen receptor 1 and N‑acetyltransferase gene expression in normal breast tissue, primary breast tumors, and established breast cancer cell lines.Carlisle SM, Hein DW.Int J Oncol. 2018 Aug; 53(2):694-702. 5.High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5α-androstane-3β,17β-Diol, or Dihydrotestosterone in Breast Cancer Cells.Zhang X, Carlisle SM, Doll MA, Martin RCG, States JC, Klinge CM, Hein DW.J Pharmacol Exp Ther. 2018 Apr; 365(1):84-93.