Search by BoMiProt ID - Bomi4022


Primary Information

BoMiProt ID Bomi4022
Protein Name Armadillo repeat-containing protein 8
Organism Bos taurus
Uniprot IDQ2KI54
Milk FractionWhey
Ref Sequence ID NP_001039923.1
Aminoacid Length 673
Molecular Weight 75451
FASTA Sequence Download
Gene Name ARMC8
Gene ID 539591
Protein Existence Status reviewed

Secondary Information

Protein Function Armc8 is involved in the negative regulation of adherens junctional CCC complex members possibly through the degradation of αE-catenin.ARMC8 binds to the N-terminal sequence of α-catenin (amino acids 82–148) and promotes its degradation to regulate cell adhesion.ARMC8 upregulates matrix metalloproteinase-7 and Snail and degrades α-catenin to disrupt the α-catenin/E-cadherin complex and promote the migration and invasion of hepatocellular carcinoma, breast cancer.ARMC8 upregulates the expression of β-catenin, cyclin D1, MMP7, and c-Myc induced by TGF-β1 by activating the canonical Wnt signaling pathway and thereby promote the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of lung cancer and bladder cancer cells
Biochemical Properties ARMC8 is highly conserved across vertebrates. It is a key component of the C-terminal of the lissencephaly type-1-like homology motif (CTLH) complex, which has E-3 ligase activity. C-terminal domain of human Armc8α is able to interact with human αE-catenin .This binding domain resides between its two armadillo domains.
Significance in milk cell–cell contacts and intracellular signaling
PTMs Acetylation and phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q2KI54|ARMC8_BOVIN Armadillo repeat-containing protein 8 OS=Bos taurus OX=9913 GN=ARMC8 PE=2 SV=1 MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVL GAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLK FIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDH QTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIF VKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEG AETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSS*337VSAITDIKRLDHDLKHAHELRQA AFKLYASLGANDEDIRKKIIDTENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRT SFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSE NPALRVNGIWALMNMAFQAEQKIKADILRSLS*512TEQLFRLLSDSDLNVLMKTLGLLRNLLS TRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDIL QKIKYYMGHSHVKLQLAAMFCISNLVWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNL CDKAKTALQQYLA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Huang Y, Jiang Z, Gao X, Luo P, Jiang X. ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases. Front Mol Biosci. 2021 Nov 29;8:791597. doi: 10.3389/fmolb.2021.791597. PMID: 34912852; PMCID: PMC8666550.