Search by BoMiProt ID - Bomi4002


Primary Information

BoMiProt ID Bomi4002
Protein Name Arginase-1/Liver-type arginase/Type I arginase
Organism Bos taurus
Uniprot IDQ2KJ64
Milk FractionWhey
Ref Sequence ID NP_001039619.1
Aminoacid Length 322
Molecular Weight 35009
FASTA Sequence Download
Gene Name ARG1
Gene ID 513608
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells liver 
Protein Function Arginase-1 is an enzyme that catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle.
PTMs Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q2KJ64|ARGI1_BOVIN Arginase-1 OS=Bos taurus OX=9913 GN=ARG1 PE=2 SV=1 MSSKPQS*7IGVIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKELECDVKDYGDLSFADNLD DS*62PFQIVKNPRCVGKASEKLADVVAEVKKTGRISLVLGGDHSLAIGSISGHARVHPDLCV IWVDAHTDINTPLTTKTGNLHGQPVSFLLKELKEKMPEVPGFYWVAPCISAKDIVYIGLR DVDPGEHYILKTLGIKYFSMTEVDKLGIGKVMEETFS*217YLLGRKKRPIHLSFDVDGLDPSF TPATGTPVQGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTTVAIT MACFGVAREGNHKPIDYLSPPK
Predicted Disorder Regions 1-7, 18-28, 134-137, 314-322
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. 
Bibliography 1.Sin YY, Baron G, Schulze A, Funk CD. Arginase-1 deficiency. J Mol Med (Berl). 2015 Dec;93(12):1287-96. doi: 10.1007/s00109-015-1354-3. Epub 2015 Oct 14. PMID: 26467175. 2.Ordóñez NG. Arginase-1 is a novel immunohistochemical marker of hepatocellular differentiation. Adv Anat Pathol. 2014 Jul;21(4):285-90. doi: 10.1097/PAP.0000000000000022. PMID: 24911253.