Search by BoMiProt ID - Bomi397


Primary Information

BoMiProt ID Bomi397
Protein Name SH3 domain-binding protein 5-like
Organism Bos taurus
Uniprot IDQ0V8K7
Milk FractionExosome
Ref Sequence ID NP_001069270.1
Aminoacid Length 385
Molecular Weight 42699
FASTA Sequence Download
Gene Name SH3BP5L
Gene ID 520254
Protein Existence Status Reveiwed:Experimental evidence at transcript level

Secondary Information

Protein Function  xSH3BP5L is required for normal embryogenesis of blastopore closure in X. laevis.SH3BP5 (Btk-SH3 domain binding protein) has been believed to negatively regulate Bruton’s tyrosine kinase activity and be a substrate of c-jun N-terminal kinase (JNK) in MAPK pathway.
PTMs Phosphorylation at Ser/Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 1-58,272-328,359-385
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.P. Cicchetti, A.J. Ridley, Y. Zheng, R.A. Cerione, D. Baltimore.3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts.EMBO J., 14 (1995), pp. 3127-3135. 2.Hu ZG, Chen Y, Zhou Q, Lv XY, Zhang Z, Wang YD, Xiao Y, Guo H, Liu YH, Tan RZ, Li QW, Bian GH, Wei YQ. Characterization of a novel Xenopus SH3 domain binding protein 5 like (xSH3BP5L) gene. Biochem Biophys Res Commun. 2008 Jan 11;365(2):214-20. doi: 10.1016/j.bbrc.2007.10.146. Epub 2007 Nov 5. PMID: 17981148.