Search by BoMiProt ID - Bomi3908


Primary Information

BoMiProt ID Bomi3908
Protein Name Ankyrin repeat and MYND domain-containing protein 2
Organism Bos taurus
Uniprot IdQ0VCS9
Milk FractionWhey
Ref Sequence Id NP_001068852.1
Aminoacid Length 442
Molecular Weight 49408
Fasta Sequence https://www.uniprot.org/uniprot/Q0VCS9.fasta
Gene Name ANKMY2
Gene Id 509032
Protein Existence Status reviewed

Secondary Information

Protein Function  as a repressor of the Hedgehog pathway via adenylyl cyclase targeting during neural tube development.
Biochemical Properties three ankyrin repeats and a MYND (myeloid, Nervy, and DEAF-1)-type Zn(2+) finger domain
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 377-442
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments Ankmy2 knockout mouse shows complete neural tube ventralization
Bibliography 1.Saita S, Shirane M, Ishitani T, Shimizu N, Nakayama KI. Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway. J Biol Chem. 2014 Sep 12;289(37):25639-54. doi: 10.1074/jbc.M114.558635. Epub 2014 Jul 30. PMID: 25077969; PMCID: PMC4162168. 2.Somatilaka BN, Hwang SH, Palicharla VR, White KA, Badgandi H, Shelton JM, Mukhopadhyay S. Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling. Dev Cell. 2020 Sep 28;54(6):710-726.e8. doi: 10.1016/j.devcel.2020.06.034. Epub 2020 Jul 22. PMID: 32702291.