Search by BoMiProt ID - Bomi3885


Primary Information

BoMiProt ID Bomi3885
Protein Name Angiopoietin-related protein 4/Angiopoietin-like protein 4
Organism Bos taurus
Uniprot IdQ2KJ51
Milk FractionWhey
Ref Sequence Id NP_001039508.1
Aminoacid Length 410
Molecular Weight 45553
Fasta Sequence https://www.uniprot.org/uniprot/Q2KJ51.fasta
Gene Name ANGPTL4
Gene Id 509963
Protein Existence Status reviewed

Secondary Information

Protein Function inhibitor of LPL that regulates circulating TG levels and lipid distributions across different tissues.induction of hyperpermeability.Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism.
Biochemical Properties Homooligomer; disulfide-linked via Cys residues in the N-terminal part of the protein.The homooligomer undergoes proteolytic processing to release the ANGPTL4 C-terminal chain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix.Forms disulfide-linked dimers and tetramers.
Significance in milk regulate the glucose and fatty acid metabolisms during the periparturient period.
PTMs N-glycosylated.Proteolysis
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q2KJ51|ANGL4_BOVIN Angiopoietin-related protein 4 OS=Bos taurus OX=9913 GN=ANGPTL4 PE=2 SV=1 MRCAPTAGAALMLCAATAGLLSAQGRPEPPETPRFASWDEVNVLAHGLLQLGHGLREHVE RTRGQLGELERRLGACGAACKDPEGSAAPPRAQANLVNPGGGDASPETLRSLKTQLEAQN SRIQQLFQKVAQQQRHLEKQQLRIQNLQSQMDHLAPRHLGHEMAKPARRKRLPKMAQLAG PAHN*184ISRLHRLPRDCQELFEEGERESGLFQIQPQGSPPFLVNCKMTSDGGWTVIQRRQDG SVDFNQPWEAYKDGFGDPQGEFWLGLEKVHHILGDRGSRLAVQLQDWEGNAESLQFPIHL GGEDTAYSLQLTPPVASKLGATTFSPSGLSLPFSTWDQDHDLRGDKNCARSLSGGWWFGT CSHSNLNGQYFHSIPRQRQQRKKGIFWKTWRGRYYPLQATTILVQPTAAS
Predicted Disorder Regions 4 predicted disordered segments; (22-36), (82-91), (119-134), (160-180)
DisProt Annotation
TM Helix Prediction 1TMH; (7-25)
Significance of PTMs Forms disulfide-linked dimers and tetramers.Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain; both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell.
Bibliography Aryal B, Price NL, Suarez Y, Fernández-Hernando C. ANGPTL4 in Metabolic and Cardiovascular Disease. Trends Mol Med. 2019 Aug;25(8):723-734. doi: 10.1016/j.molmed.2019.05.010. Epub 2019 Jun 21. PMID: 31235370; PMCID: PMC6779329.