Search by BoMiProt ID - Bomi3881


Primary Information

BoMiProt ID Bomi3881
Protein Name Angiomotin-like protein 2
Organism Bos taurus
Uniprot IDF1MRK3
Milk Fractionwhey
Ref Sequence ID XP_010799902.1
Aminoacid Length 766
Molecular Weight 84727
FASTA Sequence Download
Gene Name AMOTL2
Gene ID 538514
Protein Existence Status reviewed

Secondary Information

Protein Function It regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. It is essential for proper architecture of actin filaments. It also participates in angiogenesis.
Biochemical Properties It inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
PTMs Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|F1MRK3|AMOL2_BOVIN Angiomotin-like protein 2 OS=Bos taurus OX=9913 GN=AMOTL2 PE=2 SV=3 MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGAGGTGSPQAPMEIMAP EDSQVLQQATRQEPQGQEHQGTETHLAENGLYRLCPQPGKGEELPTY*107EEAKAHSQYYASQ QAGPWPHVGDRDPRGPPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARTPSHMSA SHSFPQLARNQQGPPARGAPTAEGPEPRGPPPQYPHVMLAHETTSAVTDPRYRARGSPHF QHAEVRILQAQVPPVFLPQQQQQYQYLQQPQERHPPPHLAALSPPGVEGPASTQASLATS GSTHLAQMETVLRENARLQRDNERLQRELESTAEKAGRIEKLESEIQRLSEAHESLTRAS SKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQ SYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALSNAQGRAARAEEELRKKQAYVEKV ERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGTPGGGGGSGGTPELSAL RLSEQLREKEEQVLALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPS PSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRKDPGKVTPGSLRPAK SVPSIFVAAAAGTQGWQGHSSSERQVDASAQLAADRAPLEEPVAVAPLAAHAKHGSRDGS TQTDGPPDSLEPDSLLGCSSGQRTAS*746LDS*749IATSRVQDFSDMVEILI
Predicted Disorder Regions 46-84, 103-109, 183-210, 253-283, 711-732, 746-758
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway
Bibliography Han, H., Yang, B., & Wang, W. (2017). Angiomotin-like 2 interacts with and negatively regulates AKT. Oncogene, 36(32), 4662–4669. https://doi.org/10.1038/onc.2017.101