Primary Information |
---|
BoMiProt ID | Bomi3881 |
---|
Protein Name | Angiomotin-like protein 2 |
---|
Organism | Bos taurus |
---|
Uniprot ID | F1MRK3 |
---|
Milk Fraction | whey |
---|
Ref Sequence ID | XP_010799902.1 |
---|
Aminoacid Length | 766 |
---|
Molecular Weight | 84727 |
---|
FASTA Sequence |
Download |
---|
Gene Name | AMOTL2 |
---|
Gene ID | 538514 |
---|
Protein Existence Status | reviewed |
---|
Secondary Information |
---|
Protein Function | It regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. It is essential for proper architecture of actin filaments. It also participates in angiogenesis. |
---|
Biochemical Properties | It inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. |
---|
PTMs | Phosphorylation |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|F1MRK3|AMOL2_BOVIN Angiomotin-like protein 2 OS=Bos taurus OX=9913 GN=AMOTL2 PE=2 SV=3
MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGAGGTGSPQAPMEIMAP
EDSQVLQQATRQEPQGQEHQGTETHLAENGLYRLCPQPGKGEELPTY*107EEAKAHSQYYASQ
QAGPWPHVGDRDPRGPPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARTPSHMSA
SHSFPQLARNQQGPPARGAPTAEGPEPRGPPPQYPHVMLAHETTSAVTDPRYRARGSPHF
QHAEVRILQAQVPPVFLPQQQQQYQYLQQPQERHPPPHLAALSPPGVEGPASTQASLATS
GSTHLAQMETVLRENARLQRDNERLQRELESTAEKAGRIEKLESEIQRLSEAHESLTRAS
SKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQ
SYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALSNAQGRAARAEEELRKKQAYVEKV
ERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGTPGGGGGSGGTPELSAL
RLSEQLREKEEQVLALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPS
PSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRKDPGKVTPGSLRPAK
SVPSIFVAAAAGTQGWQGHSSSERQVDASAQLAADRAPLEEPVAVAPLAAHAKHGSRDGS
TQTDGPPDSLEPDSLLGCSSGQRTAS*746LDS*749IATSRVQDFSDMVEILI
|
---|
Predicted Disorder Regions | 46-84, 103-109, 183-210, 253-283, 711-732, 746-758 |
---|
DisProt Annotation | |
---|
TM Helix Prediction | No TM helices |
---|
Significance of PTMs | Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway |
---|
Bibliography | Han, H., Yang, B., & Wang, W. (2017). Angiomotin-like 2 interacts with and negatively regulates AKT. Oncogene, 36(32), 4662–4669. https://doi.org/10.1038/onc.2017.101 |