Primary Information |
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BoMiProt ID | Bomi384 |
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Protein Name | Vesicle transport through interaction with t-SNAREs homolog 1B |
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Organism | Bos taurus |
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Uniprot ID | Q2KIU0 |
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Milk Fraction | MFGM |
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Ref Sequence ID | NP_001073115.1 |
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Aminoacid Length | 232 |
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Molecular Weight | 26709 |
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FASTA Sequence |
Download |
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Gene Name | VTI1B |
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Gene ID | 780809 |
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Protein Existence Status | Reviewed:Experimental evidence at transcript level |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | In macrophages, Vti1b and syntaxin 6 are localized on intracellular membranes and are present on isolated Golgi membranes and on Golgi-derived TNFα |
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Protein Function | A SNARE protein which is up-regulated in conjunction with increasing cytokine secretion in activated macrophages; Vti1b and syntaxin 6 interact to form a novel intracellular Q-SNARE complex; implicated in late endosome homotypic fusion and in late endosome-lysosome fusion |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | 1TMH; (207-229) |
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Bibliography | 1. Murray, R. Z. et al. (2005) ‘Syntaxin 6 and Vti1b Form a Novel SNARE Complex, Which Is Up-regulated in Activated Macrophages to Facilitate Exocytosis of Tumor Necrosis Factor-α’, Journal of Biological Chemistry, 280(11), pp. 10478–10483. doi: 10.1074/jbc.M414420200. |