Primary Information
BoMiProt ID	Bomi3825
Protein Name	Alpha-1-syntrophin
Organism	Bos taurus
Uniprot ID	Q0P5E6
Milk Fraction	whey
Ref Sequence ID	NP_001069366.1
Aminoacid Length	505
Molecular Weight	53873
FASTA Sequence	Download
Gene Name	SNTA1
Gene ID	527488
Protein Existence Status	Reviewed
Secondary Information
Protein Function	It serves an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse
Biochemical Properties	Interacts with the dystrophin protein DMD in a calmodulin dependent manner and with related protein UTRN; SGCA of the dystrophin glycoprotein complex; F-actin; calmodulin and with the other members of the syntrophin family SNTB1 and SNTB2.
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q0P5E6|SNTA1_BOVIN Alpha-1-syntrophin OS=Bos taurus OX=9913 GN=SNTA1 PE=2 SV=1 MASGRRAPRTGLLELRAGAGSGAGGERWQRAVLSLEEDALTVSPADGEPGPEPGAQREPE PAQLNGAAEPGAASPPLPEALLLQPRRVTVRKADAGGLGIS*101IKGGRENKMPILISKIFKG LAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKEVSPYFKNSA SGTS*184VGWDS*189PPAS*193PLQRQPS*200SPGPPPRDLRDAKHMSLKMAYVSRRCTPTDPETRYLEICSADGRDTLFLRAKDEASAKSWAAAIQAQVNTLTPRVKDELQALLSATSTAGSQDIKRIGWL TEQLPSGGTAPTLALLTEKELLLYSCLPQTREALSRPARTAPLITTRLVHSGPSKGSVPY DAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRA CSLSVHIDNGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLH SCPKTMVFIIHSFLSAKVTRLGLLA
Predicted Disorder Regions	1-9, 32-76, 181-222
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Phosphorylation may inhibit the interaction with DMD.Phosphorylated by CaM-kinase II
Bibliography	Bhat, H. F., Baba, R. A., Adams, M. E., & Khanday, F. A. (2014). Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells. British journal of cancer, 110(3), 706–714. https://doi.org/10.1038/bjc.2013.723