Primary Information |
|---|
| BoMiProt ID | Bomi3825 |
|---|
| Protein Name | Alpha-1-syntrophin |
|---|
| Organism | Bos taurus |
|---|
| Uniprot Id | Q0P5E6 |
|---|
| Milk Fraction | whey |
|---|
| Ref Sequence Id | NP_001069366.1 |
|---|
| Aminoacid Length | 505 |
|---|
| Molecular Weight | 53873 |
|---|
| Fasta Sequence | https://www.uniprot.org/uniprot/Q0P5E6.fasta |
|---|
| Gene Name | SNTA1 |
|---|
| Gene Id | 527488 |
|---|
| Protein Existence Status | Reviewed |
|---|
Secondary Information |
|---|
| Protein Function | It serves an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse |
|---|
| Biochemical Properties | Interacts with the dystrophin protein DMD in a calmodulin dependent manner and with related protein UTRN; SGCA of the dystrophin glycoprotein complex; F-actin; calmodulin and with the other members of the syntrophin family SNTB1 and SNTB2. |
|---|
| PTMs | Phosphorylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0P5E6|SNTA1_BOVIN Alpha-1-syntrophin OS=Bos taurus OX=9913 GN=SNTA1 PE=2 SV=1
MASGRRAPRTGLLELRAGAGSGAGGERWQRAVLSLEEDALTVSPADGEPGPEPGAQREPE
PAQLNGAAEPGAASPPLPEALLLQPRRVTVRKADAGGLGIS*101IKGGRENKMPILISKIFKG
LAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKEVSPYFKNSA
SGTS*184VGWDS*189PPAS*193PLQRQPS*200SPGPPPRDLRDAKHMSLKMAYVSRRCTPTDPETRYLEICSADGRDTLFLRAKDEASAKSWAAAIQAQVNTLTPRVKDELQALLSATSTAGSQDIKRIGWL
TEQLPSGGTAPTLALLTEKELLLYSCLPQTREALSRPARTAPLITTRLVHSGPSKGSVPY
DAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRA
CSLSVHIDNGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLH
SCPKTMVFIIHSFLSAKVTRLGLLA
|
|---|
| Predicted Disorder Regions | 1-9, 32-76, 181-222 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Significance of PTMs | Phosphorylation may inhibit the interaction with DMD.Phosphorylated by CaM-kinase II |
|---|
| Bibliography | Bhat, H. F., Baba, R. A., Adams, M. E., & Khanday, F. A. (2014). Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells. British journal of cancer, 110(3), 706–714. https://doi.org/10.1038/bjc.2013.723 |
|---|
