Search by BoMiProt ID - Bomi380


Primary Information

BoMiProt ID Bomi380
Protein Name Vesicle-associated membrane protein 8
Organism Bos taurus
Uniprot IDQ3T0Y8
Milk FractionExosome
Ref Sequence ID NP_001029462.1
Aminoacid Length 100
Molecular Weight 11357
FASTA Sequence Download
Gene Name VAMP8
Gene ID 507309
Protein Existence Status Reviewed: Protein inferred from homology

Secondary Information

Presence in other biological fluids/tissue/cells enriched in membrane fractions; primarily associated with the perinuclear vesicular structures of the early endocytic compartment;
Protein Function integral membrane protein; endobrevin overexpression may accelerate the process of docking/fusion of endocytic vesicles to the endosome; endobrevin can bind to both syntaxin 1A and α-SNAP; important role in vesicle recycling following by endocytosis; endobrevin overexpression decreased the glucose-stimulated insulin release
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (76-98)
Bibliography 1. Wong, S. H. et al. (1998) ‘Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome.’, Molecular biology of the cell, 9(6), pp. 1549–63. doi: 10.1091/mbc.9.6.1549.
2. Nagamatsu, S. et al. (2001) ‘Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules.’, Journal of cell science, 114(Pt 1), pp. 219–227. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11112705 (Accessed: 2 October 2019).