Search by BoMiProt ID - Bomi38


Primary Information

BoMiProt ID Bomi38
Protein Name RUVBL1 protein
Organism Bos taurus
Uniprot IdA7MBG8
Milk FractionExosome
Ref Sequence Id NP_001094546.1
Amino Acid Lenth 456
Molecular Weight 50154
Fasta Sequence https://www.uniprot.org/uniprot/A7MBG8.fasta
Gene Name RUVBL1
Gene Id 511475
Protein Existence Status Unreviewed: Experimental evidence at protein level

Secondry Information

Protein Function Integral components of multisubunit protein complexes involved in processes ranging from cellular metabolism, transcription and chromatin remodeling to DNA repair; essential for efficient mitosis and proliferation
Biochemical Properties belong to AAA+ (ATPases associated with various cellular activities) superfamily; form heterodimeric complexes with RUVBL2 in which they stabilize each other
Significance in milk induced during the transition from the proliferation to the differentiated stage of mammary gland
PTMs phosphorylate RUVBL1 by PLK1- T239 site of phosphorylation in vitro
Significance of PTMs regulation of protein in cell division
Additional Comments interact with the phosphatidylinositol kinase-like kinases (PIKKs) ATM, ATR and DNA-PK in DNA damage signaling
Bibliography 1. Desrivières, S., Kuhn, K., Müller, J., Gläser, M., Laria, N. C.-P., Korder, J., … Prinz, T. (2007). Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation. Proteomics, 7(12), 2019–2037. https://doi.org/10.1002/pmic.200600994.
2. Gentili, C., Castor, D., Kaden, S., Lauterbach, D., Gysi, M., Steigemann, P., … Ferrari, S. (2015). Chromosome Missegregation Associated with RUVBL1 Deficiency. PloS One, 10(7), e0133576. https://doi.org/10.1371/journal.pone.0133576.