Search by BoMiProt ID - Bomi3799


Primary Information

BoMiProt ID Bomi3799
Protein Name Aldo-keto reductase family 1 member B1
Organism Bos taurus
Uniprot IdP16116
Milk FractionExosomes
Ref Sequence Id NP_001012537.1
Aminoacid Length 315
Molecular Weight 35919
Fasta Sequence https://www.uniprot.org/uniprot/P16116.fasta
Gene Name AKR1B1
Gene Id 317748
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells placenta 
Protein Function AKR1B1 have been involved in different metabolic and physiological processes, such as glucose metabolism, inflammation and prostaglandin synthesis. AKR1B1 could also be considered as a potential cancer diagnostic biomarker since its promoter has shown high levels of methylation.
PTMs N6-acetylation at Lysine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Overexpression of AKR1B1 has been indicated to trigger the AKT/mTOR signalling pathway through interaction with the AKT1 kinase domain.
Bibliography 1.. Zhao JX, Yuan YW, Cai CF, et al. Aldose reductase interacts with akt1 to augment hepatic akt/mtor signaling and promote hepatocarcinogenesis. Oncotarget. 2017;8:66987‐67000. 2.Khayami R, Hashemi SR, Kerachian MA. Role of aldo-keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential. J Cell Mol Med. 2020 Aug;24(16):8890-8902. doi: 10.1111/jcmm.15581. Epub 2020 Jul 6. PMID: 32633024; PMCID: PMC7417692.