Primary Information |
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| BoMiProt ID | Bomi3799 |
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| Protein Name | Aldo-keto reductase family 1 member B1 |
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| Organism | Bos taurus |
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| Uniprot ID | P16116 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001012537.1 |
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| Aminoacid Length | 315 |
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| Molecular Weight | 35919 |
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| FASTA Sequence |
Download |
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| Gene Name | AKR1B1 |
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| Gene ID | 317748 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | placenta |
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| Protein Function | AKR1B1 have been involved in different metabolic and physiological processes, such as glucose metabolism, inflammation and prostaglandin synthesis. AKR1B1 could also be considered as a potential cancer diagnostic biomarker since its promoter has shown high levels of methylation. |
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| PTMs | N6-acetylation at Lysine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Overexpression of AKR1B1 has been indicated to trigger the AKT/mTOR signalling pathway through interaction with the AKT1 kinase domain. |
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| Bibliography | 1.. Zhao JX, Yuan YW, Cai CF, et al. Aldose reductase interacts with akt1 to augment hepatic akt/mtor signaling and promote hepatocarcinogenesis. Oncotarget. 2017;8:66987‐67000. 2.Khayami R, Hashemi SR, Kerachian MA. Role of aldo-keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential. J Cell Mol Med. 2020 Aug;24(16):8890-8902. doi: 10.1111/jcmm.15581. Epub 2020 Jul 6. PMID: 32633024; PMCID: PMC7417692. |
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