Search by BoMiProt ID - Bomi379


Primary Information

BoMiProt ID Bomi379
Protein Name Vesicle-associated membrane protein 2
Organism Bos taurus
Uniprot IDP63026
Milk FractionExosome
Ref Sequence ID NP_776908.1
Aminoacid Length 116
Molecular Weight 12649
FASTA Sequence Download
Gene Name VAMP2
Gene ID 282116
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells Synaptobrevin 1 and 2 are expressed at high concentration in brain
Protein Function type II membrane protein of small synaptic vesicles, is essential for neuroexocytosis; be involved in docking and fusion of SSV with the presynaptic membrane; play the role of vesicle receptor in the process of vesicle docking to the active zones of the presynaptic membrane; Plays a Specific Role in the Insulin-dependent Trafficking of the Facilitative Glucose Transporter GLUT4 in 3T3-L1 Adipocytes;
Biochemical Properties a minimal SNARE that consists only of a short NH2-terminal sequence, a SNARE motif, and a COOHterminal transmembrane region; Synaptobrevin-deficient synapses show an 100-fold reduction in AP-induced neurotransmitter release but only a 10-fold reduction in spontaneous release or in release triggered by hypertonic sucrose;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions
DisProt Annotation
TM Helix Prediction 1TMH; (96-114)
Bibliography 1. Washbourne, P., Schiavo, G. and Montecucco, C. (1995) ‘Vesicle-associated membrane protein-2 (synaptobrevin-2) forms a complex with synaptophysin’, Biochemical Journal, 305(3), pp. 721–724. doi: 10.1042/bj3050721.
2. Schoch, S. et al. (2001) ‘SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice’, Science, 294(5544), pp. 1117–1122. doi: 10.1126/science.1064335.
3. Washbourne, P. et al. (2002) ‘Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis’, Nature Neuroscience, 5(1), pp. 19–26. doi: 10.1038/nn783.
4. Deak, F. et al. (2006) ‘Structural Determinants of Synaptobrevin 2 Function in Synaptic Vesicle Fusion’, Journal of Neuroscience, 26(25), pp. 6668–6676. doi: 10.1523/JNEUROSCI.5272-05.2006.