Primary Information |
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| BoMiProt ID | Bomi374 |
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| Protein Name | Ubiquitin conjugation factor E4 A |
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| Organism | Bos taurus |
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| Uniprot ID | A5PKG6 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001092469.1 |
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| Aminoacid Length | 1067 |
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| Molecular Weight | 122593 |
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| FASTA Sequence |
Download |
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| Gene Name | UBE4A |
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| Gene ID | 517544 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | E4 is a protein family of ubiquitin chain assembly factors belonging to the ubiquitin proteasome system; E4
binds to the ubiquitin moieties of these conjugates and in conjunction with the E1, E2, and E3 enzymes, drives multiubiquitin chain assembly, yielding long chains; functions primarily through its ubiquitin-binding
property and that it may influence the linkage between
individual ubiquitin molecules; yeast E4 is functionally
linked to stress tolerance andmost likely mediates the
degradation of stress-induced aberrant proteins; |
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| Biochemical Properties | the E4 protein does not interact with the
substrate directly, but apparently with the ubiquitin moieties
of ubiquitin–substrate conjugates |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | (33-57) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Koegl, M. et al. (1999) ‘A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.’, Cell, 96(5), pp. 635–44. doi: 10.1016/s0092-8674(00)80574-7. |
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