Primary Information |
|---|
| BoMiProt ID | Bomi3736 |
|---|
| Protein Name | ADP-ribosylation factor GTPase-activating protein 3/ARF GAP 3 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q17R07 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001069442.1 |
|---|
| Aminoacid Length | 517 |
|---|
| Molecular Weight | 56766 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | ARFGAP3 |
|---|
| Gene ID | 532778 |
|---|
| Protein Existence Status | Reviewed |
|---|
Secondary Information |
|---|
| Protein Function | ARFGAP3 colocalized with COPI subunits in the Golgi complex and peripheral punctate structures and associated with COPI-coated vesicles generated from Golgi membranes.It is a GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1) |
|---|
| Biochemical Properties | ARFGAP3 has an N-terminal GATA1 (305371)-type zinc finger motif containing 4 cysteines that is highly conserved among ARFGAPs, as well as multiple potential phosphorylation sites. |
|---|
| PTMs | Phosphorylation on ser |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q17R07|ARFG3_BOVIN ADP-ribosylation factor GTPase-activating protein 3 OS=Bos taurus OX=9913 GN=ARFGAP3 PE=2 SV=1
MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLS
FIRSTELDSNWSWFQLRCMQVGGNANASSFFHQHGCDTNDTNAKYNSRAAQLYRERIKAL
ASQATRKHGTDLWLDSCVVPPSSPPPKEEDFFASHASPEVSSTGWASAQPEPSLTPRNVD
APAASSEGVPEQGPSVEGLNVPTKAAVGEVSSIIKKKPNQAKRGLGAKKGS*231LGAQKLSNT
CFNEIEKQAQAVDKMNAQEDLLSRAAPKEES*271IVSS*275LRLAYKDLEIQMKKDEKMNMSGKKK
AESERLGMGFGNSRSGISHSVTSDMQTIEQETPITAKPRKKYGDDSDDSYFTSSSRFFDE
PMELRSSSFSS*371WDDSSDSYWKKETIKDTDPIPKNTGYTDRPTTRRKPDSEPAENTDEAQK
KFGNVKAIS*429SDMYFGRQAKADYEARARLERLS*452AS*454SS*456IS*458S*459ADLFDEQRKQTAGSYNLTSVLPTAPDMAQFKQGVRSVAGKLSVFANGVMTSIQDRYGS
|
|---|
| Predicted Disorder Regions | 134-244, 258-269, 287-302, 321-425, 457-466 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Bibliography | Holden, J. L., Nur-E-Kamal, M. S., Fabri, L., Nice, E., Hammacher, A., & Maruta, H. (1991). Rsr1 and Rap1 GTPases are activated by the same GTPase-activating protein and require threonine 65 for their activation. The Journal of biological chemistry, 266(26), 16992–16995. |
|---|
