Search by BoMiProt ID - Bomi3734


Primary Information

BoMiProt ID Bomi3734
Protein Name ADP-ribose glycohydrolase ARH3/ADP-ribosylhydrolase 3/O-acetyl-ADP-ribose deacetylase ARH3/Poly(ADP-ribose) glycohydrolase ARH3/[Protein ADP-ribosylarginine] hydrolase-like protein 2/[Protein ADP-ribosylserine] hydrolase
Organism Bos taurus
Uniprot IdQ3SYV9
Milk Fractionwhey
Ref Sequence Id NP_001030417.1
Aminoacid Length 365
Molecular Weight 39221
Fasta Sequence https://www.uniprot.org/uniprot/Q3SYV9.fasta
Gene Name ADPRS/ADPRHL2
Gene Id 521650
Protein Existence Status Reviewed

Secondary Information

Protein Function ADP-ribose glycohydrolase ARH3 hydrolyzes the scissile α-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates. Proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose act as its substrates.It also plays role in controlling DNA damage as it behaves as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions (54-74)
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography Hanzlikova, H., Prokhorova, E., Krejcikova, K., Cihlarova, Z., Kalasova, I., Kubovciak, J., Sachova, J., Hailstone, R., Brazina, J., Ghosh, S., Cirak, S., Gleeson, J. G., Ahel, I., & Caldecott, K. W. (2020). Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair. Nature communications, 11(1), 3391. https://doi.org/10.1038/s41467-020-17069-9