Search by BoMiProt ID - Bomi3733


Primary Information

BoMiProt ID Bomi3733
Protein Name ADP-dependent glucokinase
Organism Bos taurus
Uniprot IdA2VE47
Milk FractionWhey
Ref Sequence Id NP_001075907.1
Aminoacid Length 497
Molecular Weight 54086
Fasta Sequence https://www.uniprot.org/uniprot/A2VE47.fasta
Gene Name ADPGK
Gene Id 518158
Protein Existence Status reviewed

Secondary Information

Protein Function It plays a critical role in T cell receptor activation-induced remodeling of energy metabolism
Biochemical Properties ADPGK co-localizes with ER markers calreticulin and IP3R1 (inositol-3-phosphate-receptor) as well as with the rough ER marker SRPRβ (signal recognition particle receptor). Te frst 21 amino acids of the ADPGK precursor protein is the ER-targeting sequence, whereas a highly hydrophobic amino acid stretch at position 80–100 aa was predicted to be a membrane spanning region5 , suggesting an active site protruding towards the cytosol.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (7-25)
Additional Comments ADP-dependent glucokinase (ADPGK) as a novel glucose sensor and a potential onco-target in specifically high-proliferating cells in Burkitt's lymphoma (BL)
Bibliography 1.Imle R, Wang BT, Stützenberger N, Birkenhagen J, Tandon A, Carl M, Himmelreich N, Thiel C, Gröne HJ, Poschet G, Völkers M, Gülow K, Schröder A, Carillo S, Mittermayr S, Bones J, Kamiński MM, Kölker S, Sauer SW. ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing. Sci Rep. 2019 Oct 3;9(1):14248. doi: 10.1038/s41598-019-50566-6. PMID: 31582762; PMCID: PMC6776650. 2.Tandon A, Birkenhagen J, Nagalla D, Kölker S, Sauer SW. ADP-dependent glucokinase as a novel onco-target for haematological malignancies. Sci Rep. 2020 Aug 12;10(1):13584. doi: 10.1038/s41598-020-70014-0. PMID: 32788680; PMCID: PMC7423609.