Search by BoMiProt ID - Bomi372


Primary Information

BoMiProt ID Bomi372
Protein Name Heat shock protein 75 kDa, mitochondrial
Organism Bos taurus
Uniprot IdQ2TBI4
Milk FractionMFGM
Ref Sequence Id NP_001033764.1
Amino Acid Lenth 703
Molecular Weight 79381
Fasta Sequence https://www.uniprot.org/uniprot/Q2TBI4.fasta
Gene Name TRAP1
Gene Id 514472
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Presence in other biological fluids/tissue/cells The highest expression levels of TRAF1 can be found in spleen, lung, and testis
Protein Function Also known as tumor necrosis factor receptor associated protein1 (TRAF1) is a cytoplasmic adapter proteins that can interact directly with the intracellular domains of cell surface receptors; capable of initiating programmed cell death; initiate signal transduction pathways that culminate in caspase activation and apoptosis; play an important role in modulating an early step in receptor-induced activation of NF-kB
Biochemical Properties localized in the soluble fraction of the cytoplasm of cells; trimerizes upon binding to the TNF trimer inducing association of its intracellular death domain; death domain is a protein interaction motif involved in homo- and hetero-association and is essential for the transduction of cytotoxic signals; death domainsself-associate and form large molecular mass aggregates at physiological pH;
Significance in milk heat stress proteins in mamary gland
Significance of PTMs sensitive to heat stress and mainly responsible for mammary cell protection from heat stress
Bibliography 1. Sukits, S. F. et al. (2001) ‘Solution structure of the tumor necrosis factor receptor-1 death domain’, Journal of Molecular Biology, 310(4), pp. 895–906. doi: 10.1006/jmbi.2001.4790.
2. Rothe, M. et al. (1994) ‘A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor’, Cell, 78(4), pp. 681–692. doi: 10.1016/0092-8674(94)90532-0.
3. Cao, Z. et al. (1996) ‘TRAF6 is a signal transducer for interleukin-1’, Nature, 383(6599), pp. 443–446. doi: 10.1038/383443a0.
4. Kuhné, M. R. et al. (1997) ‘Assembly and regulation of the CD40 receptor complex in human B cells.’, The Journal of experimental medicine, 186(2), pp. 337–42. doi: 10.1084/jem.186.2.337.
5. Rothe, M. et al. (1995) ‘TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40’, Science, 269(5229), pp. 1424–1427. doi: 10.1126/science.7544915.