|Protein Name||Heat shock protein 75 kDa, mitochondrial|
|Ref Sequence Id||NP_001033764.1|
|Amino Acid Lenth||703|
|Protein Existence Status||Reviewed: Experimental evidence at transcript level|
|Presence in other biological fluids/tissue/cells||The highest expression levels of TRAF1 can be found in spleen, lung, and testis|
|Protein Function||Also known as tumor necrosis factor receptor associated protein1 (TRAF1) is a cytoplasmic adapter proteins that can interact directly with the intracellular domains of cell surface receptors; capable of initiating programmed cell death; initiate signal transduction pathways that culminate in caspase activation and apoptosis; play an important role in modulating an early step in receptor-induced activation of NF-kB|
|Biochemical Properties||localized in the soluble fraction of the cytoplasm of cells; trimerizes upon binding to the TNF trimer inducing association of its intracellular death domain; death domain is a protein interaction motif involved in homo- and hetero-association and is essential for the transduction of cytotoxic signals; death domainsself-associate and form large molecular mass aggregates at physiological pH;|
|Significance in milk||heat stress proteins in mamary gland|
|Significance of PTMs||sensitive to heat stress and mainly responsible for mammary cell protection from heat stress|
|Bibliography||1. Sukits, S. F. et al. (2001) ‘Solution structure of the tumor necrosis factor receptor-1 death domain’, Journal of Molecular Biology, 310(4), pp. 895–906. doi: 10.1006/jmbi.2001.4790. |
2. Rothe, M. et al. (1994) ‘A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor’, Cell, 78(4), pp. 681–692. doi: 10.1016/0092-8674(94)90532-0.
3. Cao, Z. et al. (1996) ‘TRAF6 is a signal transducer for interleukin-1’, Nature, 383(6599), pp. 443–446. doi: 10.1038/383443a0.
4. Kuhné, M. R. et al. (1997) ‘Assembly and regulation of the CD40 receptor complex in human B cells.’, The Journal of experimental medicine, 186(2), pp. 337–42. doi: 10.1084/jem.186.2.337.
5. Rothe, M. et al. (1995) ‘TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40’, Science, 269(5229), pp. 1424–1427. doi: 10.1126/science.7544915.