Primary Information |
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BoMiProt ID | Bomi369 |
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Protein Name | Tax1-binding protein 1 homolog |
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Organism | Bos taurus |
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Uniprot ID | Q2KJE0 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001039874.1 |
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Aminoacid Length | 817 |
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Molecular Weight | 94059 |
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FASTA Sequence |
Download |
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Gene Name | TAX1BP1 |
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Gene ID | 535589 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | localizes in intranuclear speckles, at the Golgi
complex, on cytoplasmic vesicles, diffusely in the cytoplasm,
and near focal adhesion sites in the plasma membrane |
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Protein Function | Plays a key role in the negative regulation of
NF-kB and IRF3 signaling by acting in concert with the
ubiquitin-editing enzyme A20; also coordinates antiapoptotic
activities of A20; can also function as a
transcriptional coactivator for nuclear receptors and viral
transactivators; essential regulator of
innate immunity; inhibitor of IL-1-, lipopolysaccharide and TNF-induced NF-kB activation; functions as a
ubiquitin-binding adaptor protein which recruits A20 to
the ubiquitylated signaling proteins TRAF6 and RIP1, leading
to their A20-mediated deubiquitylation and the disruption
of IL-1- and TNF-induced NF-kB signaling, respectively |
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PTMs | phosphorylated at SKICH domain |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 609-685,704-742 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | may regulate the interaction between TAX1BP1 and NAP1 |
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Bibliography | 1. Fu, T. et al. (2018) ‘Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1’, Proceedings of the National Academy of Sciences, 115(50), pp. E11651–E11660. doi: 10.1073/pnas.1811421115. 2. Iha, H. et al. (2008) ‘Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation’, The EMBO Journal, 27(4), pp. 629–641. doi: 10.1038/emboj.2008.5. 3. Shembade, N. et al. (2007) ‘Essential role for TAX1BP1 in the termination of TNF-α-, IL-1- and LPS-mediated NF-κB and JNK signaling’, The EMBO Journal, 26(17), pp. 3910–3922. doi: 10.1038/sj.emboj.7601823. 4. Chin, K.-T. et al. (2007) ‘Human T-Cell Leukemia Virus Oncoprotein Tax Represses Nuclear Receptor–Dependent Transcription by Targeting Coactivator TAX1BP1’, Cancer Research, 67(3), pp. 1072–1081. doi: 10.1158/0008-5472.CAN-06-3053. |