Search by BoMiProt ID - Bomi369


Primary Information

BoMiProt ID Bomi369
Protein Name Tax1-binding protein 1 homolog
Organism Bos taurus
Uniprot IDQ2KJE0
Milk FractionExosome
Ref Sequence ID NP_001039874.1
Aminoacid Length 817
Molecular Weight 94059
FASTA Sequence Download
Gene Name TAX1BP1
Gene ID 535589
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells localizes in intranuclear speckles, at the Golgi complex, on cytoplasmic vesicles, diffusely in the cytoplasm, and near focal adhesion sites in the plasma membrane
Protein Function Plays a key role in the negative regulation of NF-kB and IRF3 signaling by acting in concert with the ubiquitin-editing enzyme A20; also coordinates antiapoptotic activities of A20; can also function as a transcriptional coactivator for nuclear receptors and viral transactivators; essential regulator of innate immunity; inhibitor of IL-1-, lipopolysaccharide and TNF-induced NF-kB activation; functions as a ubiquitin-binding adaptor protein which recruits A20 to the ubiquitylated signaling proteins TRAF6 and RIP1, leading to their A20-mediated deubiquitylation and the disruption of IL-1- and TNF-induced NF-kB signaling, respectively
PTMs phosphorylated at SKICH domain
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 609-685,704-742
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs may regulate the interaction between TAX1BP1 and NAP1
Bibliography 1. Fu, T. et al. (2018) ‘Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1’, Proceedings of the National Academy of Sciences, 115(50), pp. E11651–E11660. doi: 10.1073/pnas.1811421115.
2. Iha, H. et al. (2008) ‘Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation’, The EMBO Journal, 27(4), pp. 629–641. doi: 10.1038/emboj.2008.5.
3. Shembade, N. et al. (2007) ‘Essential role for TAX1BP1 in the termination of TNF-α-, IL-1- and LPS-mediated NF-κB and JNK signaling’, The EMBO Journal, 26(17), pp. 3910–3922. doi: 10.1038/sj.emboj.7601823.
4. Chin, K.-T. et al. (2007) ‘Human T-Cell Leukemia Virus Oncoprotein Tax Represses Nuclear Receptor–Dependent Transcription by Targeting Coactivator TAX1BP1’, Cancer Research, 67(3), pp. 1072–1081. doi: 10.1158/0008-5472.CAN-06-3053.