Search by BoMiProt ID - Bomi3653


Primary Information

BoMiProt ID Bomi3653
Protein Name Acyl-coenzyme A thioesterase 9, mitochondrial/ Acyl-CoA thioesterase 9/Acyl-CoA thioester hydrolase 9
Organism Bos taurus
Uniprot IdQ3SWX2
Milk FractionWhey
Ref Sequence Id NP_001029732.1
Aminoacid Length 437
Molecular Weight 49853
Fasta Sequence https://www.uniprot.org/uniprot/Q3SWX2.fasta
Gene Name ACOT9
Gene Id 527845
Protein Existence Status reviewed

Secondary Information

Protein Function traffics mitochondrial short-chain fatty acids towards de novo lipogenesis and glucose production in the liver. It also regulates neuronal fatty acid metabolism to prevent neurotoxicity.
Biochemical Properties Hepatic Acot9 localized to the inner mitochondrial membrane, where it deactivated short-chain but not long-chain fatty acyl-CoA. This unique localization and activity of Acot9 directed acetyl-CoA away from protein lysine acetylation and toward the citric acid (TCA) cycle. 
Significance in milk Regulation of lipid synthesis genes and milk fat production in human mammary epithelial cells during secretory activation
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Steensels S, Qiao J, Zhang Y, Maner-Smith KM, Kika N, Holman CD, Corey KE, Bracken WC, Ortlund EA, Ersoy BA. Acyl-Coenzyme A Thioesterase 9 Traffics Mitochondrial Short-Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver. Hepatology. 2020 Sep;72(3):857-872. doi: 10.1002/hep.31409. PMID: 32498134. 2.Ellis JM, Wong GW, Wolfgang MJ. Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol Cell Biol. 2013 May;33(9):1869-82. doi: 10.1128/MCB.01548-12. Epub 2013 Mar 4. PMID: 23459938; PMCID: PMC3624175.