Search by BoMiProt ID - Bomi3645


Primary Information

BoMiProt ID Bomi3645
Protein Name Acyl-CoA synthetase short-chain family member 3, mitochondrial
Organism Bos taurus
Uniprot IdA7MB45
Milk FractionWhey
Ref Sequence Id NP_001095607.1
Aminoacid Length 686
Molecular Weight 74805
Fasta Sequence https://www.uniprot.org/uniprot/A7MB45.fasta
Gene Name ACSS3
Gene Id 531552
Protein Existence Status reviewed

Secondary Information

Protein Function ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3.Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids.Restoration of ACSS3 expression in PCa cells significantly reduced LD deposits, thus promoting apoptosis by increasing endoplasmic reticulum (ER) stress.
Biochemical Properties Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate
Significance in milk bovine milk fatty acid synthesis
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography Zhou L, Song Z, Hu J, Liu L, Hou Y, Zhang X, Yang X, Chen K. ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3. Theranostics. 2021 Jan 1;11(2):841-860. doi: 10.7150/thno.49384. PMID: 33391508; PMCID: PMC7738848.