Primary Information
BoMiProt ID	Bomi360
Protein Name	Signal recognition particle receptor subunit alpha
Organism	Bos taurus
Uniprot ID	Q3MHE8
Milk Fraction	Exosome
Ref Sequence ID	NP_001068590.1
Aminoacid Length	639
Molecular Weight	69896
FASTA Sequence	Download
Gene Name	SRPRA
Gene ID	281504
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	Targets and anchors the polypeptide to the endoplasmic reticulum membrane by a mechanism independent of the pathway involving the signal recognition particle; essential for the translocation of nascent polypeptides across the ER membrane via a mechanism mediated by the signal recognition particle
Biochemical Properties	bound to the cytoplasmic face of the ER membrane largely by strong interactions with the transmembrane P subunit of the receptor; in a cell-free system, novel SRa polypeptides are assembled onto ER microsomes in a urea- and salt-resistant manner by an SRP-independent pathway
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	(132-317)
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Young, J. C. and Andrews, D. W. (1996) ‘The signal recognition particle receptor alpha subunit assembles co-translationally on the endoplasmic reticulum membrane during an mRNA-encoded translation pause in vitro.’, The EMBO journal, 15(1), pp. 172–81. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8598200 (Accessed: 2 October 2019). 2. Gilmore, R., Blobel, G. and Walter, P. (1982) ‘Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle’, The Journal of Cell Biology, 95(2), pp. 463–469. doi: 10.1083/jcb.95.2.463. 3. Gilmore, R., Walter, P. and Blobel, G. (1982) ‘Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor’, The Journal of Cell Biology, 95(2), pp. 470–477. doi: 10.1083/jcb.95.2.470. 4. Andrews, D. W. et al. (1989) ‘Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor’, The Journal of Cell Biology, 108(3), pp. 797–810. doi: 10.1083/jcb.108.3.797. 5. Young, J. C. et al. (1995) ‘An Amino-terminal Domain Containing Hydrophobic and Hydrophilic Sequences Binds the Signal Recognition Particle Receptor α Subunit to the β Subunit on the Endoplasmic Reticulum Membrane’, Journal of Biological Chemistry, 270(26), pp. 15650–15657. doi: 10.1074/jbc.270.26.15650.