Search by BoMiProt ID - Bomi359


Primary Information

BoMiProt ID Bomi359
Protein Name Spartin
Organism Bos taurus
Uniprot IDA0JNJ3
Milk FractionWhey, MFGM
Ref Sequence ID NP_001071464.1
Aminoacid Length 668
Molecular Weight 72702
FASTA Sequence Download
Gene Name SPART
Gene ID 534027
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function spartin is a multifunction protein that interacts with proteins involved with cellular activities such as long chain fatty acid metabolism, vesicle transport and protein folding/turnover and receptor-triggered endocytosis; role of spartin in protein folding and turnover both in mitochondria and endoplasmic reticulum; spartin interacts with the C-terminal regions of Eps15 and Eps15R
Biochemical Properties spartin associates with microtubules and that the N-terminal part of protein is essential for that interaction; interacting proteins: GRP78, GRP75 and nucleolin
PTMs spartin is constitutively monoubiquitinated and binds to ubiquitin
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 110-176, 348-396, 631-668
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Milewska, M., McRedmond, J. and Byrne, P. C. (2009) ‘Identification of novel spartin-interactors shows spartin is a multifunctional protein’, Journal of Neurochemistry, 111(4), pp. 1022–1030. doi: 10.1111/j.1471-4159.2009.06382.x.
2. Bakowska, J. C. et al. (2005) ‘The Troyer syndrome (SPG20) protein spartin interacts with Eps15.’, Biochemical and biophysical research communications, 334(4), pp. 1042–8. doi: 10.1016/j.bbrc.2005.06.201.
3. Lu, J., Rashid, F. and Byrne, P. C. (2006) ‘The hereditary spastic paraplegia protein spartin localises to mitochondria’, Journal of Neurochemistry, 98(6), pp. 1908–1919. doi: 10.1111/j.1471-4159.2006.04008.x.