Primary Information |
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| BoMiProt ID | Bomi3572 |
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| Protein Name | 72 kDa type IV collagenase/72 kDa gelatinase/Matrix metalloproteinase-2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q9GLE5 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_777170.1 |
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| Aminoacid Length | 661 |
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| Molecular Weight | 73777 |
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| FASTA Sequence |
Download |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. |
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| Biochemical Properties | Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. |
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| PTMs | Phosphorylation and Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q9GLE5|MMP2_BOVIN 72 kDa type IV collagenase OS=Bos taurus OX=9913 GN=MMP2 PE=2 SV=1
MTEARVSRGALAALLRALCALGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYG
CPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKW
DKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHG
DGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELRTLGEGQVVRVKYGNADGEYCKFPFRF
NGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQG
TSYDSCTTEGRTDGYRWCGTTEDYDRDKEYGFCPETAMSTVGGNSEGAPCVLPFTFLGNK
HESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGA
LMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGIS
QIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNE
YWVYSASTLERGYPKPLTSLGLPPGVQKVDAAFN*574WSKNKKTYIFAGDKFWRYNEVKKKMD
PGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLEN*643QSLKSVKFGSIKSDWLG
C
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| Predicted Disorder Regions | 1 disordered segment; (452-466) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation on multiple sites modulates enzymatic activity. |
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