|Protein Name||Staphylococcal nuclease domain-containing protein 1|
|Milk Fraction||MFGM, Exosome|
|Ref Sequence Id||NP_991353.1|
|Amino Acid Lenth||910|
|Protein Existence Status||Reviewed: Experimental evidence at protein level|
|Presence in other biological fluids/tissue/cells||ER-Golgi vesicles, enriched in secretory cells; regarded as a nuclear and/or cytoplasmic protein; extranuclear expression in b-cells|
|Protein Function||Acts as a transcriptional coactivator, namely in the secretion of lipid droplets in mammary epithelial cells and hepatocytes; acts in RNA editing and is linked to apoptosis; component of the RNA-induced splicing - complex that mediates RNA interference - leading to degradation of specific mRNAs|
|Significance in milk||transcriptional coactivator, namely in the secretion of lipid droplets in mammary epithelial cells;|
|Bibliography||1. Milochau, A. et al. (2014) ‘Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cells’, FEBS Letters, 588(14), pp. 2217–2222. doi: 10.1016/j.febslet.2014.05.031. |
2. Palacios, L. et al. (2006) ‘Overexpression of SND p102, a rat homologue of p100 coactivator, promotes the secretion of lipoprotein phospholipids in primary hepatocytes’, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1761(7), pp. 698–708. doi: 10.1016/j.bbalip.2006.05.005.
3. Caudy, A. A. et al. (2003) ‘A micrococcal nuclease homologue in RNAi effector complexes’, Nature, 425(6956), pp. 411–414. doi: 10.1038/nature01956.
4. Chen, X. et al. (2010) ‘Quantitative Proteomics Analysis of Cell Cycle-regulated Golgi Disassembly and Reassembly’, Journal of Biological Chemistry, 285(10), pp. 7197–7207. doi: 10.1074/jbc.M109.047084.
5. Kuruma, H. et al. (2009) ‘Staphylococcal Nuclease Domain-Containing Protein 1 as a Potential Tissue Marker for Prostate Cancer’, The American Journal of Pathology, 174(6), pp. 2044–2050. doi: 10.2353/ajpath.2009.080776.