Search by BoMiProt ID - Bomi3552


Primary Information

BoMiProt ID Bomi3552
Protein Name 60S ribosomal protein L23a
Organism Bos taurus
Uniprot IdQ24JY1
Milk FractionExosomes
Ref Sequence Id NP_001039423.1
Aminoacid Length 156
Molecular Weight 17695
Fasta Sequence https://www.uniprot.org/uniprot/Q24JY1.fasta
Gene Name RPL23A
Gene Id 507168
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells  testis 
Protein Function PDRL23A is found to interact with 60 S ribosomal protein L26 (RPL26), hampering RPL26-governed p53 translation, and resulting in a reduction in the level of p53 protein, which in turn reduced p53-mediated apoptosis under hypoxic conditions.
PTMs N6-Acetylation at Lys,Citrullination,Isopeptide bond formation, N,N,N-trimethylation at Ala, Phosphorylation at Ser, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q24JY1|RL23A_BOVIN 60S ribosomal protein L23a OS=Bos taurus OX=9913 GN=RPL23A PE=2 SV=1 MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTS*43PT*45FRRPKTLRLRRQPKY PRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDID VAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII
Predicted Disorder Regions (1-70)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Yin A, Feng M, Zhang L, Cheng Z, Li Y, Qian L. Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion. Pharmacol Res. 2022 Jan;175:105988. doi: 10.1016/j.phrs.2021.105988. Epub 2021 Nov 19. PMID: 34808368. 2.