Primary Information |
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BoMiProt ID | Bomi354 |
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Protein Name | SHC-transforming protein 1 |
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Organism | Bos taurus |
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Uniprot ID | Q0IIE2 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001068773.1 |
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Aminoacid Length | 473 |
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Molecular Weight | 51631 |
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FASTA Sequence |
Download |
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Gene Name | SHC1 |
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Gene ID | 507196 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | present in the intracellular compartment |
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Protein Function | help to transduce an extracellular signal into an intracellular signal, which is then translated into a biological response; Shc family of docking proteins is an essential element in signalling cascades mediated by different extracellular signals, including growth factors, cytokines and integrins; generally exert their action by activating mitogen-activated protein kinases (MAPK) and phosphoinositide-3-kinase/Akt signalling pathways; contribute to mediating several intracellular signalling cascades; they are implicated in cell proliferation, cell differentiation, cell survival and migration |
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PTMs | Shc proteins can be phosphorylated by tyrosine kinases
on certain conserved tyrosine residues contained within
the CH1 region |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 1-26,216-314,328-349 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | tyrosine phosphorylation is a requirement
for the coupling of the PTB and SH2 domains in Shc with
other proteins |
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Bibliography | 1. Conti, L. et al. (2001) ‘Shc signaling in differentiating neural progenitor cells’, Nature Neuroscience, 4(6), pp. 579–586. doi: 10.1038/88395. 2. Collins, L. R. et al. (1999) ‘Bifurcation of Cell Migratory and Proliferative Signaling by the Adaptor Protein Shc’, The Journal of Cell Biology, 147(7), pp. 1561–1568. doi: 10.1083/jcb.147.7.1561. 3. Smith, M. J. et al. (2010) ‘The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1’, The EMBO Journal, 29(5), pp. 884–896. doi: 10.1038/emboj.2009.399. 4. Gu, H. et al. (2000) ‘New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway.’, Molecular and cellular biology, 20(19), pp. 7109–20. doi: 10.1128/mcb.20.19.7109-7120.2000. |