Search by BoMiProt ID - Bomi354


Primary Information

BoMiProt ID Bomi354
Protein Name SHC-transforming protein 1
Organism Bos taurus
Uniprot IDQ0IIE2
Milk FractionExosome
Ref Sequence ID NP_001068773.1
Aminoacid Length 473
Molecular Weight 51631
FASTA Sequence Download
Gene Name SHC1
Gene ID 507196
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells present in the intracellular compartment
Protein Function help to transduce an extracellular signal into an intracellular signal, which is then translated into a biological response; Shc family of docking proteins is an essential element in signalling cascades mediated by different extracellular signals, including growth factors, cytokines and integrins; generally exert their action by activating mitogen-activated protein kinases (MAPK) and phosphoinositide-3-kinase/Akt signalling pathways; contribute to mediating several intracellular signalling cascades; they are implicated in cell proliferation, cell differentiation, cell survival and migration
PTMs Shc proteins can be phosphorylated by tyrosine kinases on certain conserved tyrosine residues contained within the CH1 region
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 1-26,216-314,328-349
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs tyrosine phosphorylation is a requirement for the coupling of the PTB and SH2 domains in Shc with other proteins
Bibliography 1. Conti, L. et al. (2001) ‘Shc signaling in differentiating neural progenitor cells’, Nature Neuroscience, 4(6), pp. 579–586. doi: 10.1038/88395.
2. Collins, L. R. et al. (1999) ‘Bifurcation of Cell Migratory and Proliferative Signaling by the Adaptor Protein Shc’, The Journal of Cell Biology, 147(7), pp. 1561–1568. doi: 10.1083/jcb.147.7.1561.
3. Smith, M. J. et al. (2010) ‘The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1’, The EMBO Journal, 29(5), pp. 884–896. doi: 10.1038/emboj.2009.399.
4. Gu, H. et al. (2000) ‘New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway.’, Molecular and cellular biology, 20(19), pp. 7109–20. doi: 10.1128/mcb.20.19.7109-7120.2000.