Search by BoMiProt ID - Bomi3536


Primary Information

BoMiProt ID Bomi3536
Protein Name 5-demethoxyubiquinone hydroxylase, mitochondrial/DMQ hydroxylase/Timing protein clk-1 homolog/Ubiquinone biosynthesis monooxygenase COQ7
Organism Bos taurus
Uniprot IdQ2TBW2
Milk Fractionwhey
Ref Sequence Id NP_001106712.1
Aminoacid Length 217
Molecular Weight 24361
Fasta Sequence https://www.uniprot.org/uniprot/Q2TBW2.fasta
Gene Name COQ7
Gene Id 504771
Protein Existence Status Reviewed

Secondary Information

Protein Function involved in the pathway ubiquinone biosynthesis.
Biochemical Properties Binds 2 iron ions per subunit.Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
PTMs Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Coq7p remains phosphorylated in fermentative conditions and becomes dephosphorylated when respiratory metabolism is induced.
Bibliography 1.Martín-Montalvo A, González-Mariscal I, Padilla S, Ballesteros M, Brautigan DL, Navas P, Santos-Ocaña C. Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. Biochem J. 2011 Nov 15;440(1):107-14. doi: 10.1042/BJ20101422. PMID: 21812761. 2.Lu, T. T., Lee, S. J., Apfel, U. P., & Lippard, S. J. (2013). Aging-associated enzyme human clock-1: substrate-mediated reduction of the diiron center for 5-demethoxyubiquinone hydroxylation. Biochemistry, 52(13), 2236–2244. https://doi.org/10.1021/bi301674p