Primary Information
BoMiProt ID	Bomi3536
Protein Name	5-demethoxyubiquinone hydroxylase, mitochondrial/DMQ hydroxylase/Timing protein clk-1 homolog/Ubiquinone biosynthesis monooxygenase COQ7
Organism	Bos taurus
Uniprot ID	Q2TBW2
Milk Fraction	whey
Ref Sequence ID	NP_001106712.1
Aminoacid Length	217
Molecular Weight	24361
FASTA Sequence	Download
Gene Name	COQ7
Gene ID	504771
Protein Existence Status	Reviewed
Secondary Information
Protein Function	involved in the pathway ubiquinone biosynthesis.
Biochemical Properties	Binds 2 iron ions per subunit.Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Coq7p remains phosphorylated in fermentative conditions and becomes dephosphorylated when respiratory metabolism is induced.
Bibliography	1.Martín-Montalvo A, González-Mariscal I, Padilla S, Ballesteros M, Brautigan DL, Navas P, Santos-Ocaña C. Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. Biochem J. 2011 Nov 15;440(1):107-14. doi: 10.1042/BJ20101422. PMID: 21812761. 2.Lu, T. T., Lee, S. J., Apfel, U. P., & Lippard, S. J. (2013). Aging-associated enzyme human clock-1: substrate-mediated reduction of the diiron center for 5-demethoxyubiquinone hydroxylation. Biochemistry, 52(13), 2236–2244. https://doi.org/10.1021/bi301674p