Search by BoMiProt ID - Bomi353


Primary Information

BoMiProt ID Bomi353
Protein Name Secretoglobin family 1D member
Organism Bos taurus
Uniprot IdA0JNP2
Milk FractionWhey, MFGM
Ref Sequence Id NP_001071275.1
Amino Acid Lenth 102
Molecular Weight 11294
Fasta Sequence https://www.uniprot.org/uniprot/A0JNP2.fasta
Gene Name SCGB1D
Gene Id 338419
Protein Existence Status Reviewed: Protein inferred from homology

Secondry Information

Presence in other biological fluids/tissue/cells breast carcinomas, estrogen receptor positive tumors; abundantly expressed in normal and malignant tissue from the breast, cervix, uterus, ovary, kidney and prostate; Lower or rare lipophilin B expression was found in normal colon, pancreas, heart, in gastric and rectal tumors, and as previously reported in normal testis and placenta and lung tumors; lipophilin B expression was also detected in the normal anterior pituitary and pituitary adenomas, in normal adrenal gland, cartilage, retina, skin, and salivary gland
Protein Function Secretoglobins are small, secreted proteins increasingly recognized for their prognostic capacity in a variety of human cancers, though the precise pathophysiologic functions for most members remain to be elucidated
Biochemical Properties Also known as lipophilin B; small and secretory; dimeric proteins; in breast cancer mammaglobin A and lipophilin B proteins form a covalent complex, and that the two proteins are bonded in a head-to-tail orientation; lipophilin binds PS, PA, or PG preferentially over PC
Significance in milk More in colustrum; role in lipid droplet transport and nutrient delivery
Bibliography 1. Boggs, J. M. et al. (1977) ‘Lipid phase separation induced by a hydrophobic protein in phosphatidylserine-phosphatidylcholine vesicles’, Biochemistry, 16(11), pp. 2325–2329. doi: 10.1021/bi00630a003.
2. Ni, J. et al. (2000) ‘All human genes of the uteroglobin family are localized on chromosome 11q12.2 and form a dense cluster.’, Annals of the New York Academy of Sciences, 923(1), pp. 25–42. doi: 10.1111/j.1749-6632.2000.tb05517.x.
3. Sjödin, A. et al. (2003) ‘Dysregulated secretoglobin expression in human lung cancers.’, Lung cancer (Amsterdam, Netherlands), 41(1), pp. 49–56. doi: 10.1016/s0169-5002(03)00126-0.
4. O’Brien, N. et al. (2002) ‘Mammaglobin a: a promising marker for breast cancer.’, Clinical chemistry, 48(8), pp. 1362–4. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12142396 (Accessed: 3 October 2019).
5. Carter, D. et al. (2003) ‘Serum antibodies to lipophilin B detected in late stage breast cancer patients.’, Clinical cancer research : an official journal of the American Association for Cancer Research, 9(2), pp. 749–54. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12576445 (Accessed: 3 October 2019).
6. Colpitts, T. L. et al. (2001) ‘Mammaglobin Is Found in Breast Tissue as a Complex with BU101’, Biochemistry, 40(37), pp. 11048–11059. doi: 10.1021/bi010284f.
7. Zafrakas, M. et al. (2006) ‘Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their co-expression in gynecologic malignancies’, BMC Cancer, 6(1), p. 88. doi: 10.1186/1471-2407-6-88.