Search by BoMiProt ID - Bomi352


Primary Information

BoMiProt ID Bomi352
Protein Name D-3-phosphoglycerate dehydrogenase
Organism Bos taurus
Uniprot IdQ5EAD2
Milk FractionExosome
Ref Sequence Id NP_001030189.1
Amino Acid Lenth 533
Molecular Weight 56452
Fasta Sequence https://www.uniprot.org/uniprot/Q5EAD2.fasta
Gene Name PHGDH
Gene Id 505103
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Protein Function catalyzes the first step in the pathway by converting D-3- phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate (PHP) concomitant with the reduction of NAD+;
Biochemical Properties catalytic activity is regulated by feedback inhibition by L-serine; human enzyme appears to contain bound cofactor when isolated and the binding order appears to be coenzyme before substrate; slowly convert αKG to αHG
Significance in milk synthesise L-serine, an important nutrient for brain function and development
Bibliography 1. Davis, J. L. and Fallon, H. J. (1970) ‘Studies on the role of 3-phosphoglycerate dehydrogenase in the regulation of serine biosynthesis in rat liver.’, The Journal of biological chemistry, 245(21), pp. 5838–46. Available at: http://www.ncbi.nlm.nih.gov/pubmed/5479453 (Accessed: 3 October 2019).
2. NAGAMACHI, S. et al. (2018) ‘Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice’, Journal of Veterinary Medical Science, 80(2), pp. 235–241. doi: 10.1292/jvms.17-0577.