Primary Information |
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| BoMiProt ID | Bomi351 |
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| Protein Name | Semaphorin-4A |
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| Organism | Bos taurus |
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| Uniprot ID | Q5EA85 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001068908.1 |
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| Aminoacid Length | 762 |
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| Molecular Weight | 83627 |
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| FASTA Sequence |
Download |
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| Gene Name | SEMA4A |
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| Gene ID | 510239 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | detectable
in adult brain, lung, kidney, testis, and spleen; preferentially expressed by dendritic cells |
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| Protein Function | Emaphorins are a large family of secreted and membrane bound
glycoproteins, initially implicated in
axon guidance and neural development; class IV are transmembrane proteins; plays an important role in the immune systemby inducing T cell activation; regulate angiogenesis; potential
player for the allergic airway inflammatory diseases; regulates the function of dendritic
cells and T lymphocytes and inhibits EC migration and experimental
angiogenesis |
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| Biochemical Properties | Become soluble after proteolytic
cleavage; may be both chemorepellent and
chemoattractive on endothelial cells |
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| Significance in milk | Mastitis induces forebrain embryonic zinc
finger-like (FEZL) expression in mammary
glands, and induced FEZL promotes expression of the axon-attracting molecule semaphorin 5A (SEMA5A) through a GCAG sequence; FEZL also induces SEMA5A expression in susceptible cattle but at a
lower level than in resistant cattle; control both neuronal development and innate immunity |
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| PTMs | Glycosylated: consensus N-linked glycosylation sites a found in semaphorin 3F in the human nervous system |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Meda, C. et al. (2012) ‘Semaphorin 4A Exerts a Proangiogenic Effect by Enhancing Vascular Endothelial Growth Factor-A Expression in Macrophages’, The Journal of Immunology, 188(8), pp. 4081–4092. doi: 10.4049/jimmunol.1101435.
2. Toyofuku, T. et al. (2007) ‘Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1’, The EMBO Journal, 26(5), pp. 1373–1384. doi: 10.1038/sj.emboj.7601589.
3. Lu, N. et al. (2018) ‘Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4’, Nature Communications. Nature Publishing Group, 9(1), p. 742. doi: 10.1038/s41467-018-03128-9.
4. Sugimoto, M. et al. (2006) ‘Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance’, Proceedings of the National Academy of Sciences, 103(17), pp. 6454–6459. doi: 10.1073/pnas.0601015103. |
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