Search by BoMiProt ID - Bomi3499


Primary Information

BoMiProt ID Bomi3499
Protein Name 3-hydroxyisobutyrate dehydrogenase, mitochondrial
Organism Bos taurus
Uniprot IdQ2HJD7
Milk FractionWhey
Ref Sequence Id NP_001039571.1
Aminoacid Length 336
Molecular Weight 35410
Fasta Sequence https://www.uniprot.org/uniprot/Q2HJD7.fasta
Gene Name HIBADH
Gene Id 512002
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells HIBADH is primarily expressed in the mitochondria of the liver, kidney, muscle, and cultured neuron cells
Protein Function sperm-motility marker. Participates in L-valine degradation pathway, which is part of Amino-acid degradation.
Biochemical Properties Tetrameric mitochondrial enzyme.Belongs to oxidoreductases,acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.Catalyses the following reaction-3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + H+ + NADH
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments methylation in the 5'-flanking region could affect the bovine sperm motility through the regulation of HIBADH gene transcriptional activity.
Bibliography Zhang S, Zhang Y, Yang C, Ju Z, Wang X, Jiang Q, Sun Y, Huang J, Zhong J, Wang C. The g.-165 T>C Rather than Methylation Is Associated with Semen Motility in Chinese Holstein Bulls by Regulating the Transcriptional Activity of the HIBADH Gene. PLoS One. 2015 Jul 2;10(7):e0127670. doi: 10.1371/journal.pone.0127670. PMID: 26133183; PMCID: PMC4489673.