Search by BoMiProt ID - Bomi3498


Primary Information

BoMiProt ID Bomi3498
Protein Name 3-hydroxyacyl-CoA dehydrogenase type-2/17-beta-estradiol 17-dehydrogenase/3-hydroxy-2-methylbutyryl-CoA dehydrogenase /Endoplasmic reticulum-associated amyloid beta-peptide-binding protein/Short chain dehydrogenase/reductase family 5C member 1
Organism Bos taurus
Uniprot IdO02691
Milk FractionWhey
Ref Sequence Id NP_776759.1
Aminoacid Length 261
Molecular Weight 27140
Fasta Sequence https://www.uniprot.org/uniprot/O02691.fasta
Gene Name HSD17B10
Gene Id 281809
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells liver
Protein Function The short-chain l-3-hydroxyacyl-CoA dehydrogenase (SCHAD) protein is involved in the penultimate step of mitochondrial fatty acid oxidation. common variants in HADHSC on chromosome 4q22-26 might be associated with development of type 2 diabetes.
Biochemical Properties  The catalytic entity reveals an alpha/beta short chain alcohol dehydrogenase/reductase (SDR) fold and the conformation of the bound nicotinamide adenine dinucleotide (NAD(+)) found in other SDR enzymes. 
PTMs N-acetylation at Ala
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.van Hove EC, Hansen T, Dekker JM, Reiling E, Nijpels G, Jørgensen T, Borch-Johnsen K, Hamid YH, Heine RJ, Pedersen O, Maassen JA, 't Hart LM. The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study. Diabetes. 2006 Nov;55(11):3193-6. doi: 10.2337/db06-0414. PMID: 17065362.