Primary Information |
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| BoMiProt ID | Bomi3484 |
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| Protein Name | 2-oxoglutarate dehydrogenase, mitochondrial/2-oxoglutarate dehydrogenase complex component E1/Alpha-ketoglutarate dehydrogenase |
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| Organism | Bos taurus |
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| Uniprot ID | Q148N0 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069498.1 |
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| Aminoacid Length | 1023 |
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| Molecular Weight | 115808 |
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| FASTA Sequence |
Download |
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| Gene Name | OGDH |
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| Gene ID | 534599 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | heart |
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| Protein Function | Alpha-ketoglutarate dehydrogenase (alpha-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. |
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| Biochemical Properties | It catalyses the conversion of alpha-ketoglutarate to succinyl-CoA and produces NADH directly providing electrons for the respiratory chain. |
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| PTMs | N6-Acetylation at Lys, Isopeptide bond formation, Phosphorylation at Ser, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q148N0|ODO1_BOVIN 2-oxoglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=OGDH PE=2 SV=1
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFGQIRCYTAPVAAEPFLSGTSSNYVEE
MYYAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLS*100PGSLSAVARAGPLVEAQPNV
DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES
DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
PGVMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN
GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR
VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV
YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP
EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY
AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR
SMTCPSTGLTEDILTHIGNVASSVPVEDFTIHGGLSRILKTRGELVKNRTVDWALAEYMA
FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL
SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP
HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH
VLRRQILLPFRKPLIIFTPKSLLRHPEARSNFDEMLPGTHFQRVIPEDGPAAQNPGNVKR
LLFCTGKVYYDLTRERKARDMVEQVAITRIEQLSPFPFDLLLQEVQKYPSAELAWCQEEH
KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDAFK
NFS
|
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Alpha-KGDH is sensitive to reactive oxygen species (ROS) and inhibition of this enzyme could be critical in the metabolic deficiency induced by oxidative stress. |
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| Bibliography | 1.Tretter L, Adam-Vizi V. Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress. Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2335-45. doi: 10.1098/rstb.2005.1764. PMID: 16321804; PMCID: PMC1569585. 2.McLain AL, Szweda PA, Szweda LI. α-Ketoglutarate dehydrogenase: a mitochondrial redox sensor. Free Radic Res. 2011 Jan;45(1):29-36. doi: 10.3109/10715762.2010.534163. Epub 2010 Nov 29. PMID: 21110783; PMCID: PMC3169906. |
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