Primary Information |
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| BoMiProt ID | Bomi3483 |
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| Protein Name | 2-hydroxyacyl-CoA lyase 2/Acetolactate synthase-like protein/IlvB-like protein |
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| Organism | Bos taurus |
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| Uniprot Id | A6QQT9 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001015535.1 |
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| Aminoacid Length | 632 |
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| Molecular Weight | 68110 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/A6QQT9.fasta |
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| Gene Name | ILVBL/AHAS/ HACL2 |
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| Gene Id | 506955 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | peroxisomal enzyme.the degradation of 3-methyl-branched fatty acids like phytanic acid and (ii) the shortening of 2-hydroxy long-chain fatty acids. splitting of a carbon-carbon bond between the first and second carbon atom in a 2-hydroxyacyl-CoA intermediate leading to the production of an (n-1) aldehyde and formyl-CoA. |
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| Biochemical Properties | homotetramer and has a PTS (peroxisomal targeting signal) at the C-terminal side (PTS1).subunits of 63 kDa |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH;(11-33) |
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| Bibliography | Casteels M, Sniekers M, Fraccascia P, Mannaerts GP, Van Veldhoven PP. The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids. Biochem Soc Trans. 2007 Nov;35(Pt 5):876-80. doi: 10.1042/BST0350876. PMID: 17956236. |
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