Search by BoMiProt ID - Bomi3483


Primary Information

BoMiProt ID Bomi3483
Protein Name 2-hydroxyacyl-CoA lyase 2/Acetolactate synthase-like protein/IlvB-like protein
Organism Bos taurus
Uniprot IdA6QQT9
Milk FractionWhey
Ref Sequence Id NP_001015535.1
Aminoacid Length 632
Molecular Weight 68110
Fasta Sequence https://www.uniprot.org/uniprot/A6QQT9.fasta
Gene Name ILVBL/AHAS/ HACL2
Gene Id 506955
Protein Existence Status reviewed

Secondary Information

Protein Function  peroxisomal enzyme.the degradation of 3-methyl-branched fatty acids like phytanic acid and (ii) the shortening of 2-hydroxy long-chain fatty acids. splitting of a carbon-carbon bond between the first and second carbon atom in a 2-hydroxyacyl-CoA intermediate leading to the production of an (n-1) aldehyde and formyl-CoA.
Biochemical Properties homotetramer and has a PTS (peroxisomal targeting signal) at the C-terminal side (PTS1).subunits of 63 kDa
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH;(11-33)
Bibliography Casteels M, Sniekers M, Fraccascia P, Mannaerts GP, Van Veldhoven PP. The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids. Biochem Soc Trans. 2007 Nov;35(Pt 5):876-80. doi: 10.1042/BST0350876. PMID: 17956236.